Q059U7
PR
Gene name |
Intu (Kiaa1284, Pdzd6) |
Protein name |
Protein inturned |
Names |
Inturned planar cell polarity effector homolog, PDZ domain-containing protein 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:380614 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q059U7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7Q3E | EM | 335 A | B | 54-942 | PDB |
| AF-Q059U7-F1 | Predicted | AlphaFoldDB |
64 variants for Q059U7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs231280285 | 4 | L>P | No | EVA | |
| rs3388629694 | 4 | L>V | No | EVA | |
| rs3388612029 | 34 | A>D | No | EVA | |
| rs3388631872 | 43 | S>Y | No | EVA | |
| rs264459367 | 79 | L>F | No | EVA | |
| rs50389608 | 103 | D>E | No | EVA | |
| rs254013828 | 111 | S>P | No | EVA | |
| rs258544488 | 136 | S>N | No | EVA | |
| rs47098933 | 151 | S>T | No | EVA | |
| rs47802448 | 172 | R>K | No | EVA | |
| rs3388631915 | 197 | K>M | No | EVA | |
| rs231634239 | 199 | S>N | No | EVA | |
| rs3388631043 | 239 | N>S | No | EVA | |
| rs255853181 | 273 | R>W | No | EVA | |
| rs46863142 | 285 | S>W | No | EVA | |
| rs3388631882 | 293 | L>F | No | EVA | |
| rs3388631902 | 348 | R>K | No | EVA | |
| rs3388631031 | 355 | C>F | No | EVA | |
| rs3393032036 | 356 | D>E | No | EVA | |
| rs30982493 | 400 | P>S | No | EVA | |
| rs3388617851 | 407 | M>V | No | EVA | |
| rs3388617793 | 419 | Y>D | No | EVA | |
| rs3388628430 | 428 | Q>H | No | EVA | |
| rs3388612046 | 439 | F>I | No | EVA | |
| rs3388631853 | 451 | K>N | No | EVA | |
| rs248197042 | 461 | Q>E | No | EVA | |
| rs3388626059 | 462 | Q>H | No | EVA | |
| rs3388626227 | 476 | G>R | No | EVA | |
| rs3388626160 | 477 | V>L | No | EVA | |
| rs3388626101 | 536 | K>N | No | EVA | |
| rs3388612061 | 545 | Y>* | No | EVA | |
| rs3388630976 | 585 | A>S | No | EVA | |
| rs230289367 | 597 | V>I | No | EVA | |
| rs3388628958 | 619 | T>I | No | EVA | |
| rs3388626211 | 620 | G>E | No | EVA | |
| rs3412087285 | 625 | D>Y | No | EVA | |
| rs47732867 | 634 | A>V | No | EVA | |
| rs3388623436 | 647 | E>Q | No | EVA | |
| rs3388626153 | 648 | E>K | No | EVA | |
| rs3388631022 | 660 | C>Y | No | EVA | |
| rs217027680 | 667 | A>T | No | EVA | |
| rs231096311 | 671 | K>R | No | EVA | |
| rs3388625708 | 706 | F>S | No | EVA | |
| rs3388631864 | 726 | E>K | No | EVA | |
| rs263219988 | 735 | A>T | No | EVA | |
| rs3388626204 | 735 | A>V | No | EVA | |
| rs3388625724 | 758 | L>H | No | EVA | |
| rs3388624220 | 789 | M>I | No | EVA | |
| rs3388628538 | 794 | G>A | No | EVA | |
| rs3388620984 | 826 | S>P | No | EVA | |
| rs3388612037 | 855 | K>R | No | EVA | |
| rs31341771 | 857 | A>T | No | EVA | |
| rs235914371 | 860 | D>A | No | EVA | |
| rs3388623881 | 865 | E>D | No | EVA | |
| rs251854498 | 866 | P>S | No | EVA | |
| rs220631703 | 867 | T>A | No | EVA | |
| rs235214150 | 868 | N>I | No | EVA | |
| rs235214150 | 868 | N>S | No | EVA | |
| rs252600803 | 873 | L>R | No | EVA | |
| rs3388617833 | 881 | V>M | No | EVA | |
| rs3388628387 | 885 | C>S | No | EVA | |
| rs245136253 | 888 | E>G | No | EVA | |
| rs3388628548 | 909 | F>S | No | EVA | |
| rs1133750843 | 925 | V>A | No | EVA |
No associated diseases with Q059U7
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| ciliary transition zone | A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
24 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| embryonic digit morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. |
| establishment of planar polarity | Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates. |
| hair follicle morphogenesis | The process in which the anatomical structures of the hair follicle are generated and organized. |
| intraciliary transport | The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. |
| keratinocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. |
| limb development | The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. |
| motile cilium assembly | The aggregation, arrangement and bonding together of a set of components to form a motile cilium. |
| negative regulation of cell division | Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. |
| negative regulation of keratinocyte proliferation | Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neural tube development | The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. |
| non-motile cilium assembly | The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. |
| positive regulation of smoothened signaling pathway | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| protein localization to organelle | A process in which a protein is transported to, or maintained in, a location within an organelle. |
| regulation of cilium assembly | Any process that modulates the frequency, rate or extent of cilium assembly. |
| regulation of ossification | Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| regulation of smoothened signaling pathway | Any process that modulates the frequency, rate or extent of smoothened signaling. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
| smoothened signaling pathway | The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. |
| spinal cord dorsal/ventral patterning | The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. |
| tongue morphogenesis | The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGLARGDSR | GRPPELPGDL | SSQEEEEEEG | DSDAGASSLG | SYSSASSDTD | VEPEWLDSVQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNGELFYLEL | SEDEEESLLP | ETQTANHVNH | VRFSDKEVII | EEDDSRERKK | SEPKLRRFTK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILKSKSLLPR | RHHKKSSSNN | GPVSILKHQS | SQKTGVTVQQ | RYKDVTVYIN | PRKLTAIKAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EQVKLLEVLV | GIIHQTKRSW | KRSAKQADGE | RLVVHGLLPG | GSAMKSGQVL | VGDVLVAVND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDVTSENIER | VLSCIPGPMQ | VKLTFENAYA | VKRETAQPQK | KKAQSSTQDL | VKLLCGSEAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVQHSTLSIP | HISMYLTLQL | QSEAAREEQE | ILYHYPVSEA | SQKLKSVRGI | FLTLCDMLES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VTGTQVTSSS | LHLNGKQIHV | AYLKESDKLL | LIGLPAEEVP | LPQLRNMIED | VAQTLKFMYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLDSAFCQVE | NAPRLDHFFS | LFFERALRPG | KLHLSGSPSA | QQYAAASAVL | LDNLPGVRWL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VLPQELKVEL | DTALSDLEAA | DFEELSEDYY | DMRRLYTILG | SSLFYKGYMV | CSHLPKDDVI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EIAAYCRQHC | LLPLAAKQRI | GQLIIWREVF | PRHHLQPPSD | SDPEAFQEPE | GRYFLLVVGL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RHYLLCVLLE | AGGCASKATG | NPGPDCIYVD | QVRATLHQLE | GVDSRIEEQL | ATSPGPCLSC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ADWFLAAPRE | KADSLTTSPI | LSRLQGPSKT | AASPTCRRTF | FSDYSFKARK | PSPSRIGGGR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EPTEGEESAG | LSPHATPDAV | RKQRESEGSD | DNVALLKLAR | KKSTLPNPFH | LGTSKKELSE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KELEVYDIMK | LTSGPENTLF | HYVALETVQG | IFITPTHEEV | AQLGGSVHSQ | LIKNFHQCCL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SIRAFFQQTL | KEEKKKALSD | GEHSEPTNSV | SSLSPVKEHG | VLFECSPENW | TDQKKTPPVM |
| 910 | 920 | 930 | 940 | ||
| SYWVVGRLFL | NPKPQELYVC | FHDSVSEIAI | EMAFKLFFGL | TL |