Q05964

PR
Gene name
FHT
Protein name
Naringenin,2-oxoglutarate 3-dioxygenase
Names
FHT, Flavanone-3-hydroxylase, F3H
Species
Dianthus caryophyllus (Carnation) (Clove pink)
KEGG Pathway
EC number
1.14.11.9: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

310-365 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05964

Entry ID Method Resolution Chain Position Source
AF-Q05964-F1 Predicted AlphaFoldDB

No variants for Q05964

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05964

No associated diseases with Q05964

3 regional properties for Q05964

Type Name Position InterPro Accession
domain Fumarase C, C-terminal 452 - 504 IPR018951
conserved_site Fumarate lyase, conserved site 361 - 370 IPR020557
domain Fumarate lyase, N-terminal 55 - 386 IPR022761

Functions

Description
EC Number 1.14.11.9 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
metal ion binding Binding to a metal ion.
naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2.

1 GO annotations of biological process

Name Definition
flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVAEKPKTLT SLEGDDKLNS NFVRDEDERP KVAYNEFSND IPVISLAGID GEKRGEICRK
70 80 90 100 110 120
IVEACEDWGI FQVVDHGVGD DLIADMTRLA REFFALPAEE KLRFDMSGGK KGGFIVSSHL
130 140 150 160 170 180
QGEVVQDWRE IVTYFSYPTN SRDYTRWPDK PEGWIKVTEE YSNKLMTLAC TLLGVLSEAM
190 200 210 220 230 240
GLELEALTKA CVDMDQKIVV NYYPKCPQPD LTLGLKRHTD PGTITLLLQD QVGGLQATRD
250 260 270 280 290 300
GGKTWITVQP VPGAFVVNLG DHGHFLSNGR FKNADHQAVV NSECSRLSIA TFQNPSPDAT
310 320 330 340 350 360
VYPLAIREGE NSIMEEPITF ADLYRRKMAK DLEIARHKRL AKEEMPFKEL DEAKFESKSI
DQILA