Q05963

PR
Gene name
FHT
Protein name
Naringenin,2-oxoglutarate 3-dioxygenase
Names
FHT, Flavanone-3-hydroxylase, F3H
Species
Callistephus chinensis (China aster) (Callistemma chinense)
KEGG Pathway
EC number
1.14.11.9: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05963

Entry ID Method Resolution Chain Position Source
AF-Q05963-F1 Predicted AlphaFoldDB

No variants for Q05963

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05963

No associated diseases with Q05963

3 regional properties for Q05963

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 188 - 292 IPR005123
domain Non-haem dioxygenase N-terminal domain 38 - 151 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 193 - 291 IPR044861

Functions

Description
EC Number 1.14.11.9 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
metal ion binding Binding to a metal ion.
naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2.

1 GO annotations of biological process

Name Definition
flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAPISLKWE EHSLHENKFV RDEDERPKVP YNTFSNEIPV ISLAGIDGCR RAEICDEIVK
70 80 90 100 110 120
ACEDWGIFQV VDHGVDTKLL SDMTGLARDF FHLPTQEKLR FDMTGGKKGG FIVSSHLQGE
130 140 150 160 170 180
AVQDWREIVT YFSYPIKARD YSRWPDKPNE WRAVTEEYSK VLMGLACKLL EVLSEAMGLE
190 200 210 220 230 240
KEALTKACVD MDQKVVVNYY PKCPQPDLTL GLKRHTDPGT ITLLLQDQVG GLQATRDGGE
250 260 270 280 290 300
SWITVKPVEG AFVVNLGDHG HYLSNGRFKN ADHQAVVNSS TSRLSIATFQ NPAPEAIVYP
310 320 330 340 350
LKINEGEKSI MEEPMTFMEM YKKKMSTDLE LARLKKLAKD KQQDLEVVKP IQNIFA