Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

2 structures for Q05957

Entry ID Method Resolution Chain Position Source
1ZLP X-ray 270 A A/B 1-318 PDB
AF-Q05957-F1 Predicted AlphaFoldDB

No variants for Q05957

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05957

No associated diseases with Q05957

2 regional properties for Q05957

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 142 - 147 IPR018523
domain ICL/PEPM domain 31 - 273 IPR039556

Functions

Description
EC Number 3.7.1.1 In ketonic substances
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
citramalate lyase activity Catalysis of the reaction: S-citramalate = acetate + pyruvate.
magnesium ion binding Binding to a magnesium (Mg) ion.
oxaloacetase activity Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate.
protein homodimerization activity Binding to an identical protein to form a homodimer.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

1 GO annotations of biological process

Name Definition
oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPPNGTTNG ETEVATQGSY TAVSTGRKTT MHRLIEEHGS VLMPGVQDAL SAAVVEKTGF
70 80 90 100 110 120
HAAFVSGYSV SAAMLGLPDF GLLTTTEVVE ATRRITAAAP NLCVVVDGDT GGGGPLNVQR
130 140 150 160 170 180
FIRELISAGA KGVFLEDQVW PKKCGHMRGK AVVPAEEHAL KIAAAREAIG DSDFFLVART
190 200 210 220 230 240
DARAPHGLEE GIRRANLYKE AGADATFVEA PANVDELKEV SAKTKGLRIA NMIEGGKTPL
250 260 270 280 290 300
HTPEEFKEMG FHLIAHSLTA VYATARALVN IMKILKEKGT TRDDLDQMAT FSEFNELISL
310
ESWYEMESKF KNFTPKAT