Q05728
Gene name |
PUR5 (At3g55010, F28P10.10, T15C9.10) |
Protein name |
Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic |
Names |
AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G55010 |
EC number |
6.3.3.1: Cyclo-ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q05728
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q05728-F1 | Predicted | AlphaFoldDB |
24 variants for Q05728
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02506328 | 6 | L>F | No | 1000Genomes | |
| ENSVATH00419944 | 18 | A>T | No | 1000Genomes | |
| ENSVATH06317323 | 26 | S>F | No | 1000Genomes | |
| ENSVATH02506331 | 32 | P>L | No | 1000Genomes | |
| ENSVATH06317324 | 35 | V>I | No | 1000Genomes | |
| tmp_3_20386945_C_G | 43 | T>R | No | 1000Genomes | |
| ENSVATH02506332 | 56 | R>G | No | 1000Genomes | |
| ENSVATH02506333 | 58 | D>H | No | 1000Genomes | |
| ENSVATH12766435 | 60 | D>N | No | 1000Genomes | |
| ENSVATH06317325 | 125 | I>T | No | 1000Genomes | |
| ENSVATH12766440 | 134 | V>I | No | 1000Genomes | |
| tmp_3_20387601_G_A | 182 | A>T | No | 1000Genomes | |
| tmp_3_20387774_A_G | 212 | K>R | No | 1000Genomes | |
| tmp_3_20387777_C_G | 213 | T>S | No | 1000Genomes | |
| ENSVATH00419956 | 215 | V>A | No | 1000Genomes | |
| tmp_3_20387799_C_A | 220 | N>K | No | 1000Genomes | |
| tmp_3_20387815_G_A | 226 | V>I | No | 1000Genomes | |
| ENSVATH00419960 | 255 | K>N | No | 1000Genomes | |
| ENSVATH06317331 | 309 | P>Q | No | 1000Genomes | |
| ENSVATH00419962 | 320 | A>T | No | 1000Genomes | |
| tmp_3_20388287_A_G | 331 | Q>R | No | 1000Genomes | |
| ENSVATH12766462 | 362 | R>Q | No | 1000Genomes | |
| ENSVATH06317332 | 371 | D>A | No | 1000Genomes | |
| tmp_3_20388533_G_C | 385 | G>A | No | 1000Genomes |
No associated diseases with Q05728
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.3.1 | Cyclo-ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| copper ion binding | Binding to a copper (Cu) ion. |
| phosphoribosylamine-glycine ligase activity | Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. |
| phosphoribosylformylglycinamidine cyclo-ligase activity | Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' IMP biosynthetic process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. |
| adenine biosynthetic process | The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. |
| purine nucleotide biosynthetic process | The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEARILQSSS | SCYSSLYAVN | RSRFSSVSSP | KPFSVSFAQT | TRTRTRVLSM | SKKDGRTDKD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDTDSLNYKD | SGVDIDAGAE | LVKRIAKMAP | GIGGFGGLFP | LGDSYLVAGT | DGVGTKLKLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FETGIHDTIG | IDLVAMSVND | IITSGAKPLF | FLDYFATSRL | DVDLAEKVIK | GIVEGCRQSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CALLGGETAE | MPDFYAEGEY | DLSGFAVGIV | KKTSVINGKN | IVAGDVLIGL | PSSGVHSNGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLVRRVLARS | NLSLKDALPG | GSSTLGDALM | APTVIYVKQV | LDMIEKGGVK | GLAHITGGGF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TDNIPRVFPD | GLGAVIHTDA | WELPPLFKWI | QQTGRIEDSE | MRRTFNLGIG | MVMVVSPEAA |
| 370 | 380 | ||||
| SRILEEVKNG | DYVAYRVGEV | VNGEGVSYQ |