Q05468

PR
Gene name
RQC1
Protein name
Ribosome quality control complex subunit 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR333C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-291 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05468

Entry ID Method Resolution Chain Position Source
AF-Q05468-F1 Predicted AlphaFoldDB

16 variants for Q05468

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1135282 49 N>D No SGRP
s04-1135276 51 V>I No SGRP
s04-1135260 56 N>S No SGRP
s04-1135238 63 M>I No SGRP
s04-1135212 72 A>V No SGRP
s04-1135182 82 G>A No SGRP
s04-1135018 137 K>E No SGRP
s04-1134733 232 P>S No SGRP
s04-1134478 317 V>I No SGRP
s04-1134087 447 S>N No SGRP
s04-1133809 540 E>K No SGRP
s04-1133754 558 S>L No SGRP
s04-1133712 572 P>R No SGRP
s04-1133683 582 T>A No SGRP
s04-1133629 600 V>I No SGRP
s04-1133482 649 I>V No SGRP

No associated diseases with Q05468

No regional properties for Q05468

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q05468

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
RQC complex A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
rescue of stalled ribosome A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.
ribosome-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSRALRRLQ DDNALLESLL SNSNANKMTS GKSTAGNIQK RENIFSMMNN VRDSDNSTDE
70 80 90 100 110 120
GQMSEQDEEA AAAGERDTQS NGQPKRITLA SKSSRRKKNK KAKRKQKNHT AEAAKDKGSD
130 140 150 160 170 180
DDDDDEEFDK IIQQFKKTDI LKYGKTKNDD TNEEGFFTAS EPEEASSQPW KSFLSLESDP
190 200 210 220 230 240
GFTKFPISCL RHSCKFFQND FKKLDPHTEF KLLFDDISPE SLEDIDSMTS TPVSPQQLKQ
250 260 270 280 290 300
IQRLKRLIRN WGGKDHRLAP NGPGMHPQHL KFTKIRDDWI PTQRGELSMK LLSSDDLLDW
310 320 330 340 350 360
QLWERPLDWK DVIQNDVSQW QKFISFYKFE PLNSDLSKKS MMDFYLSVIV HPDHEALINL
370 380 390 400 410 420
ISSKFPYHVP GLLQVALIFI RQGDRSNTNG LLQRALFVFD RALKANIIFD SLNCQLPYIY
430 440 450 460 470 480
FFNRQFYLAI FRYIQSLAQR GVIGTASEWT KVLWSLSPLE DPLGCRYFLD HYFLLNNDYQ
490 500 510 520 530 540
YIIELSNSPL MNCYKQWNTL GFSLAVVLSF LRINEMSSAR NALLKAFKHH PLQLSELFKE
550 560 570 580 590 600
KLLGDHALTK DLSIDGHSAE NLELKAYMAR FPLLWNRNEE VTFLHDEMSS ILQDYHRGNV
610 620 630 640 650 660
TIDSNDGQDH NNINNLQSPF FIAGIPINLL RFAILSEESS VMAAIPSFIW SDNEVYEFDV
670 680 690 700 710 720
LPPMPTSKES IEVVENIKTF INEKDLAVLQ AERMQDEDLL NQIRQISLQQ YIHENEESNE
NEG