Q053V5

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
KEGG Pathway
lbl:LBL_0835
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-266 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q053V5

Entry ID Method Resolution Chain Position Source
AF-Q053V5-F1 Predicted AlphaFoldDB

No variants for Q053V5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q053V5

No associated diseases with Q053V5

5 regional properties for Q053V5

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 201 - 350 IPR010918-1
domain PurM-like, C-terminal domain 578 - 715 IPR010918-2
domain PurM-like, N-terminal domain 86 - 188 IPR016188-1
domain PurM-like, N-terminal domain 458 - 562 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 10 - 51 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKDVVSLQD ALEHGLTAEE FQKIQEILGR IPNSTELGIF SAMWSEHCSY KNSVLKLKTL
70 80 90 100 110 120
PTSSDKLLAK AGEENAGAMD IGDGLAVVFK IESHNHPTAV EPYQGAATGV GGIMRDIFTM
130 140 150 160 170 180
GARPIVSLNS LRFGNPDEPR NKYLLSRAVK GIGDYGNSLG IAVSGGELFI DECFSKNPLV
190 200 210 220 230 240
NAMTVGIVRH DQMASATTGG QVGNAVYIVG ATTGRDGIHG ASFASKDLSK ESESKRSAVQ
250 260 270 280 290 300
VGDPFMEKLL MEASLEAIQK GLLIGIQDMG AAGISCATSE MSAKGKTGMK IDLDLVPFRE
310 320 330 340 350 360
TGMNAYEVML SESQERMLVV PKKGKESELV SIFEKWNLNA VRIGEVTADG FIEIYMGGKL
370 380 390 400 410 420
KAHIPAESLV LGGGAPRYER ETKRPSYLDA VKTWKPNSIL DITPGANTKD VLLNILSSWN
430 440 450 460 470 480
VCSRKPITEQ YDSEVGLVKL IGPGLDGGLS SIPDTNKALA TATDCNSRYT YLDPYKGAQF
490 500 510 520 530 540
AVCEAARNVY VTGATPYGVT NNLNFANPYI PENYYMFSEC IRGMGDACRF LGLPVTGGNV
550 560 570 580 590 600
SFYNESPEGP IFPTPTIGMV GILQDKKKFL SNFPKEVGIE LAVLGNFRPS LGGSEYLKKI
610 620 630 640 650 660
HGQVNGSIPE IDIKEELELC KLILSLNEKG ALKSARDLSL GGIGIALSKT ILFSGLGIDA
670 680 690 700 710 720
ELIAFKQSRL DLTLFGESST TVLVGFDSSW KEKIREQTEE KGLKFYPVGK TTSSELLKLK
730 740
DIGVEVSFSE LNGPYEKGLE VVFAL