Q05311

PR
Gene name
uvrD (STM3951, STMD1.39)
Protein name
DNA helicase II
Names
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM3951
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

619-697 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05311

Entry ID Method Resolution Chain Position Source
AF-Q05311-F1 Predicted AlphaFoldDB

No variants for Q05311

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05311

No associated diseases with Q05311

2 regional properties for Q05311

Type Name Position InterPro Accession
domain UvrD-like helicase, ATP-binding domain 8 - 286 IPR014016
domain UvrD-like DNA helicase, C-terminal 277 - 616 IPR014017

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
DNA helicase complex A protein complex that possesses DNA helicase activity.

4 GO annotations of molecular function

Name Definition
3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

3 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDVSYLLDSL NDKQREAVAA PRSNMLVLAG AGSGKTRVLV HRIAWLLSVE NNSPYSIMAV
70 80 90 100 110 120
TFTNKAAAEM RHRIGQLMGT SQGGMWVGTF HGLAHRLLRA HHMDANLPQD FQILDSEDQM
130 140 150 160 170 180
RLLKRLIKAM NLDEKQWPPR QAMWYINSQK DEGLRPHHIQ SYGNPVEQTW QKVYQAYQEA
190 200 210 220 230 240
CDRAGLVDFA ELLLRAHELW LNKPHILQHY RERFTNILVD EFQDTNNIQY AWVRLLAGDT
250 260 270 280 290 300
GKVMIVGDDD QSIYGWRGAQ VENIQRFLND FPGAQTIRLE QNYRSTSNIL SAANALIENN
310 320 330 340 350 360
NGRLGKKLWT DGVDGEPISL YCAFNELDEA RFVVNRIKTW QDNGGALAQC AILYRSNAQS
370 380 390 400 410 420
RVLEEALLQA SMPYRIYGGM RFFERQEIKD ALSYLRLIAN RNDDAAFERV VNTPTRGIGD
430 440 450 460 470 480
RTLDVVRQTS RDRQLTLWQV CRELLQEKAL AGRAASALQR FMELIDALAQ ETADMPLHVQ
490 500 510 520 530 540
TDRVIKDSGL RTMYEQEKGE KGQTRIENLE ELVTATRQFS YNDEDEDLMP LQAFLSHAAL
550 560 570 580 590 600
EAGEGQADTW QDAVQLMTLH SAKGLEFPQV FIVGMEEGMF PSQMSLDEGG RLEEERRLAY
610 620 630 640 650 660
VGVTRAMQKL TLTYAETRRL YGKEVYHRPS RFIGELPEEC VEEVRLRATV SRPVSHQRMG
670 680 690 700 710
TPLAENDTGY KLGQRVRHAK FGEGTIVNLE GSGEHSRLQV AFQGQGIKWL VAAYAKLETV