Q050Q1

PR
Gene name
lysS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
KEGG Pathway
lbl:LBL_1747
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q050Q1

Entry ID Method Resolution Chain Position Source
AF-Q050Q1-F1 Predicted AlphaFoldDB

No variants for Q050Q1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q050Q1

No associated diseases with Q050Q1

4 regional properties for Q050Q1

Type Name Position InterPro Accession
domain AAA+ ATPase domain 238 - 380 IPR003593
domain ATPase, AAA-type, core 242 - 378 IPR003959
conserved_site ATPase, AAA-type, conserved site 350 - 369 IPR003960
domain AAA ATPase, AAA+ lid domain 400 - 459 IPR041569

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDSNELIQQ RIQKIEDLKN QGINPYPVRF FPDSKSKDIV EKFEKDPTGP ETKFKLGGRL
70 80 90 100 110 120
HSKRVMGKAS FAHLKDSTGI IQLYATRDDL GEISYSIFKS LDLGDIIGLE GYLFKTQKGE
130 140 150 160 170 180
VTLHVTSVEL LAKCIRPLPV VKEKDGVIYD AFADVEQRYR MRYVDLVVND HVRDTFITRS
190 200 210 220 230 240
RIVSEIRNFL TNEGFLEVET PMMQPIAGGA AARPFVTHHN TLDMQLFLRI APELYLKRLI
250 260 270 280 290 300
VGGMDRVFEL NRNFRNEGIS TKHNPEFTMM EAYIAFADMN TMLDLTERLI THLAQKIHGA
310 320 330 340 350 360
LKIQYGKDLI DLSPPWRKIT YTDIIKEYSG IDFSLITSLE EAKKKASELN VDVSKCNTIW
370 380 390 400 410 420
KVADEVFSEK AEPNLIQPVF IIDYPKELSP LAKSNPDKPG YVERFEPYVA GREIGNAFTE
430 440 450 460 470 480
LNDPFDQKER FEDQVQQREA GDDEAFMMDE DYIRALEYGM PPTGGLGIGI DRLVMLLTDS
490
HSIRDTILFP LMRPE