Q05068
Gene name |
hisB |
Protein name |
Imidazoleglycerol-phosphate dehydratase |
Names |
IGPD |
Species |
Nostoc sp (strain PCC 7120 / SAG 2582 / UTEX 2576) |
KEGG Pathway |
ana:all4390 |
EC number |
4.2.1.19: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q05068
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q05068-F1 | Predicted | AlphaFoldDB |
No variants for Q05068
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q05068 | |||||
No associated diseases with Q05068
2 regional properties for Q05068
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Imidazoleglycerol-phosphate dehydratase, conserved site | 75 - 88 | IPR020565-1 |
| conserved_site | Imidazoleglycerol-phosphate dehydratase, conserved site | 170 - 182 | IPR020565-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.19 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| imidazoleglycerol-phosphate dehydratase activity | Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQISDYPQLN | LSSVPRIASV | HRITGETNVQ | VTVNLDGTGI | CKAATGIPFL | DHMLHQISSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLIDLDVQAK | GDWEIDDHHT | NEDVGITLGQ | ALAKALGDRK | GIVRFGNFLA | PLDEALVQVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDFSGRPHLS | YGLQIPTERV | GTYDTQLVRE | FFVALVNHSQ | MTLHIRQLDG | INSHHIIEAT |
| 190 | 200 | ||||
| FKAFARAARM | AIEVDPRRAG | TIPSSKGVL |