Q04WF7

PR
Gene name
dnaA
Protein name
Chromosomal replication initiator protein DnaA
Names
Species
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
KEGG Pathway
lbj:LBJ_0004
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04WF7

Entry ID Method Resolution Chain Position Source
AF-Q04WF7-F1 Predicted AlphaFoldDB

No variants for Q04WF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q04WF7

No associated diseases with Q04WF7

4 regional properties for Q04WF7

Type Name Position InterPro Accession
domain AAA+ ATPase domain 131 - 261 IPR003593
domain Chromosomal replication initiator, DnaA C-terminal 345 - 433 IPR013159
domain Chromosomal replication initiator protein DnaA 101 - 316 IPR013317
domain DnaA N-terminal domain 4 - 62 IPR024633

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

2 GO annotations of biological process

Name Definition
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLAWNKILE EVSKKISPQY YERFIDTLKL ETLNSEKCTI IAPSATIKTH VERKYQSIIE
70 80 90 100 110 120
NAILEACGDK IPVEILIETK ATSPLQSFLE KSFDQKDFQF NPDYTFETFI VGDCNRLAYT
130 140 150 160 170 180
AAKECVRKPA EINPLYLFGS VGVGKTHLLH AIGSELIKKD PWKTVCYIDI SSFMNEFRFA
190 200 210 220 230 240
LQSRELIESF KIKYQSYNCL LVDDIQLLST NAEKTQDEFF ALFNFLFERK RQIVIASDRP
250 260 270 280 290 300
SSELTIHERL KSRFVTGVQA DIQYPNKEIR KGIVTSHSKI MDLGLSEDVL EFLADQIEED
310 320 330 340 350 360
TRLLLGALND IYLYKKSYSL LFLNLDKVKE IVKNRLYRKK NVEFSHDRII ESVAKEFNLD
370 380 390 400 410 420
AAEIMGKSRK KELIIPRHIC FYLLHNVFNV NKSQVGRLFQ TQHTTVIHGL RKTEELLSDN
430
KEIRFLVERI SSKYKLQ