Q04947
Gene name |
RTN1 (YDR233C) |
Protein name |
Reticulon-like protein 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR233C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q04947
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04947-F1 | Predicted | AlphaFoldDB |
11 variants for Q04947
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-930226 | 43 | L>W | No | SGRP | |
| s04-930095 | 87 | P>T | No | SGRP | |
| s04-930073 | 94 | A>V | No | SGRP | |
| s04-930056 | 100 | H>N | No | SGRP | |
| s04-930055 | 100 | H>R | No | SGRP | |
| s04-929896 | 153 | A>G | No | SGRP | |
| s04-929774 | 194 | C>G | No | SGRP | |
| s04-929690 | 222 | V>M | No | SGRP | |
| s04-929656 | 233 | T>S | No | SGRP | |
| s04-929654 | 234 | S>T | No | SGRP | |
| s04-929474 | 294 | N>D | No | SGRP |
No associated diseases with Q04947
1 regional properties for Q04947
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Reticulon | 20 - 220 | IPR003388 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cortical endoplasmic reticulum | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum tubular network | A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of cytoplasmic side of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum inheritance | The partitioning of endoplasmic reticulum between daughter cells at cell division. |
| endoplasmic reticulum organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. |
| endoplasmic reticulum tubular network maintenance | The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. |
| endoplasmic reticulum tubular network organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. |
| ER-dependent peroxisome organization | A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum. |
| nuclear pore complex assembly | The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASAQHSQA | QQQQQQKSCN | CDLLLWRNPV | QTGKYFGGSL | LALLILKKVN | LITFFLKVAY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TILFTTGSIE | FVSKLFLGQG | LITKYGPKEC | PNIAGFIKPH | IDEALKQLPV | FQAHIRKTVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQVPKHTFKT | AVALFLLHKF | FSWFSIWTIV | FVADIFTFTL | PVIYHSYKHE | IDATVAQGVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ISKQKTQEFS | QMACEKTKPY | LDKVESKLGP | ISNLVKSKTA | PVSSTAGPQT | ASTSKLAADV |
| 250 | 260 | 270 | 280 | 290 | |
| PLEPESKAYT | SSAQVMPEVP | QHEPSTTQEF | NVDELSNELK | KSTKNLQNEL | EKNNA |