Q04804

PR
Gene name
pfeS (PA2687)
Protein name
Sensor protein PfeS
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA2687
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q04804

Entry ID Method Resolution Chain Position Source
3KYZ X-ray 150 A A 28-149 PDB
AF-Q04804-F1 Predicted AlphaFoldDB

No variants for Q04804

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q04804

No associated diseases with Q04804

8 regional properties for Q04804

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 338 - 446 IPR003594
domain HAMP domain 174 - 233 IPR003660
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 232 - 293 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 375 - 389 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 393 - 403 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 407 - 425 IPR004358-3
domain Histidine kinase domain 241 - 446 IPR005467
domain Two-component histidine kinase, sensor domain 38 - 148 IPR031930

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

1 GO annotations of biological process

Name Definition
phosphorelay signal transduction system A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRHPLLWKL ALLQVGFCLL LTWLIYTWGL SVERSTYFLA PADRHYLADY ARQAEDAWRR
70 80 90 100 110 120
EGAAGAERFR KELSAKEDTW VALVGPHLES LGSTPLSAEE SSHLTFMRKL DWPMSRRLQD
130 140 150 160 170 180
ELPYVSIEFP GHPEQGRLVI QLPERLLPGG LTPWTHLVTH GIVPTLLAAL LGLLLYRHLV
190 200 210 220 230 240
VPLNRLRDRA DALRADELES TPLAAPLAAR RDELGELAQA LEHMAERLRL SLAQQRLLLR
250 260 270 280 290 300
TLSHELRTPL ARLRIAHDSE LPPEQLRQRL DREIGDMQRL LEDTLDLAWM DTERPQLPTE
310 320 330 340 350 360
PVLALSVWEA LRDDACFESG WDPARLPCRL GVDCRVEVHL DSLAQAMENL LRNAIRHSPE
370 380 390 400 410 420
DGTVSLDGER EGDFWHLRLQ DQGPGVAEDQ LERIFLPYQR LDDSAGEGFG LGLAIARRAI
430 440
ELQGGRLWAS NGKPGLCLHL WLPAAA