Q04772

PR
Gene name
IRC21 (YMR073C, YM9916.12C)
Protein name
Increased recombination centers protein 21
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR073C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04772

Entry ID Method Resolution Chain Position Source
AF-Q04772-F1 Predicted AlphaFoldDB

5 variants for Q04772

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-412814 20 A>V No SGRP
s13-412788 29 H>D No SGRP
s13-412782 31 A>T No SGRP
s13-412694 60 S>I No SGRP
s13-412377 166 I>L No SGRP

No associated diseases with Q04772

2 regional properties for Q04772

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 122 - 200 IPR001199
binding_site Cytochrome b5, heme-binding site 154 - 161 IPR018506

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSDGMNRDV SNSKPNVRFA APQRLSVAHP AISSPLHMPM SKSSRKPLVR TKIRLDPGHS
70 80 90 100 110 120
ALDWHSLTSN PANYYTKFVS LQLIQDLLDD PVFQKDNFKF SPSQLKNQLL VQKIPLYKIM
130 140 150 160 170 180
PPLRINRKIV KKHCKGEDEL WCVINGKVYD ISSYLKFHPG GTDILIKHRN SDDLITYFNK
190 200
YHQWVNYEKL LQVCFIGVVC E