Q04511
Gene name |
UFO1 (YML088W) |
Protein name |
Ubiquitin ligase complex F-box protein UFO1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YML088W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q04511
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04511-F1 | Predicted | AlphaFoldDB |
8 variants for Q04511
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-92253 | 7 | V>L | No | SGRP | |
| s13-92586 | 118 | A>T | No | SGRP | |
| s13-93091 | 286 | R>Q | No | SGRP | |
| s13-93235 | 334 | D>G | No | SGRP | |
| s13-93396 | 388 | V>I | No | SGRP | |
| s13-93762 | 510 | L>F | No | SGRP | |
| s13-93961 | 576 | N>S | No | SGRP | |
| s13-94071 | 613 | R>* | No | SGRP |
No associated diseases with Q04511
5 regional properties for Q04511
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | F-box domain | 5 - 52 | IPR001810 |
| conserved_site | Ubiquitin interacting motif | 517 - 536 | IPR003903-1 |
| conserved_site | Ubiquitin interacting motif | 547 - 566 | IPR003903-2 |
| conserved_site | Ubiquitin interacting motif | 583 - 602 | IPR003903-3 |
| conserved_site | Ubiquitin interacting motif | 651 - 668 | IPR003903-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| cellular response to methylmercury | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERPGLVLQD | LPPEILINIF | SHLDEKDLFT | LQELSTHFRN | LIHDEELWKN | LFKSRVHTTH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPTFSQSSKF | SVEYIERTRG | LHHWQHNKAI | RTKYTIIPTR | NWDQPSIERI | VFDYPRVAAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDGTITILQL | QNHKRQKKFK | KLIYIPCTTP | QGCSTMDFNI | NAAVFGRFDG | RVFGKLLSNK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYLTPVMEFT | GRHSAGVTAI | CNSESWDTSR | EDWSVSGSEN | GEIIWWCENK | LVKMWKVSNR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIWKLAFFKD | WTLIMDDEKL | YIIHQMQELH | SIDIPKDLDE | QPMRVRFFKM | DFGSMTLVLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLNNVYTISV | NPNGNFGNLR | KLEMPEQICA | VEIDEKTSQR | EQNWQFAGDD | GCYISLLTTQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NTLYIINIRD | LSSSGLKVQC | KISFDEQVYV | SQVTNLIVVV | ALPNVLQILN | AMTGELIKTV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKTEKFPEFL | KVSQDKIIMG | SGNVLNYLKF | VSSDSKKHHH | STKGKNTVSN | KWNETLNTEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QYYDEDEDLR | RKRQSEISRL | IDAYGGDLEL | SGDTDEENDI | QLRIALLESQ | EAQARNQAEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GEPVGDDEDE | QLRRALEESQ | LIYETQTNSS | ANHGNNTNDE | IDEDDEEFLR | AIRQSRVEDE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RRRHLRNHTT | GRRNGPLSDD | NFATYGAAES | SERTSTENTI | GSSVGVDASN | NVDEDLQLAI |
| ALSLSEIN |