Q044C3

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63)
KEGG Pathway
lga:LGAS_0808
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

173-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q044C3

Entry ID Method Resolution Chain Position Source
AF-Q044C3-F1 Predicted AlphaFoldDB

No variants for Q044C3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q044C3

No associated diseases with Q044C3

6 regional properties for Q044C3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 94 - 456 IPR002314
domain Anticodon-binding 473 - 562 IPR004154
domain Aminoacyl-tRNA synthetase, class II 33 - 465 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 257 - 374 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 455 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 470 - 561 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRQSKFFMPT LKEAPSDAVA KSHQLMLRGG YIRQVTAGVY AYLPLGYRVL RKAENIIEEE
70 80 90 100 110 120
MNNINVPEMI MPHLLPATLW QESGRYKKYG AEMFKLQDRH GRESLLGPTH EETFTEIVAK
130 140 150 160 170 180
NLKSYKQMPL ALYQIQTKFR DENRPRFGLL RGREFVMLDG YSFAATREQL DEQFDDQKSA
190 200 210 220 230 240
YLKIFNRAGV TVHPVIADSG TMGGKNSTEF QAPAAIGEDT IATNEKGTYA ANLEMAKSID
250 260 270 280 290 300
TFKQDPEDAK ELTKVATPGM DTIDKLAEFL KVPATRIVKS ILYIADDQKV LVLIRGDKEI
310 320 330 340 350 360
NEVKLGHVLD ADEVRTANAD ELVEITGSEK GGVGPIGADW ADKIVADETV KGLYNVVVGA
370 380 390 400 410 420
NETDYQYQNA NLDRDFKVDE FADIRTANEG ELDPVDHLPL KFTTSIEVGH IFKLGTYYTK
430 440 450 460 470 480
TMGADFLDNN GKAKPVIMGS YGIGVTRMLS AAVEQHLTEN GIAWPKEIAP FDVHLIQMKM
490 500 510 520 530 540
KDEAQTELAE KLEKELSTKY DVLYDDRNER PGVKFNDADL VGAPLRITIG RKAKDGIVEV
550 560
KRPTDEKAME VNISDLDAMI TKELG