Q04377

PR
Gene name
LCD1 (DDC2, PIE1, YDR499W)
Protein name
DNA damage checkpoint protein LCD1
Names
DNA damage checkpoint protein 2, Lethal, checkpoint-defective, DNA damage-sensitive protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR499W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-217 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for Q04377

Entry ID Method Resolution Chain Position Source
5OMD X-ray 210 A A 73-136 PDB
5X6O EM 390 A G 1-747 PDB
6Z2W EM 282 A C/D 1-747 PDB
6Z2X EM 320 A C/D 1-747 PDB
6Z3A EM 380 A C/D 1-747 PDB
7WZR EM 470 A D/E 1-747 PDB
7WZW EM 380 A C/D 1-747 PDB
8B4J X-ray 158 A P 4-24 PDB
AF-Q04377-F1 Predicted AlphaFoldDB

17 variants for Q04377

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1447829 3 R>Q No SGRP
s04-1447869 16 D>E No SGRP
s04-1447935 38 L>F No SGRP
s04-1447951 44 T>A No SGRP
s04-1447954 45 T>A No SGRP
s04-1448092 91 K>E No SGRP
s04-1448333 171 P>L No SGRP
s04-1448512 231 L>F No SGRP
s04-1448578 253 S>P No SGRP
s04-1448737 306 I>V No SGRP
s04-1448837 339 V>A No SGRP
s04-1449115 432 I>V No SGRP
s04-1449164 448 S>N No SGRP
s04-1449398 526 G>E No SGRP
s04-1449421 534 A>T No SGRP
s04-1449917 699 M>T No SGRP
s04-1450033 738 A>S No SGRP

No associated diseases with Q04377

1 regional properties for Q04377

Type Name Position InterPro Accession
domain Diacylglycerol kinase, catalytic domain 224 - 368 IPR001206

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks
  • The recruitment to DNA lesion sites requires the presence of the RPA complex on DNA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ATR-ATRIP complex A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.

7 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
establishment of protein localization The directed movement of a protein to a specific location.
nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of double-strand break repair Any process that modulates the frequency, rate or extent of double-strand break repair.
telomere maintenance via telomerase The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRETVGEFS SDDDDDILLE LGTRPPRFTQ IPPSSAALQT QIPTTLEVTT TTLNNKQSKN
70 80 90 100 110 120
DNQLVNQLNK AQGEASMLRD KINFLNIERE KEKNIQAVKV NELQVKHLQE LAKLKQELQK
130 140 150 160 170 180
LEDEKKFLQM EARGKSKREV ITNVKPPSTT LSTNTNTITP DSSSVAIEAK PQSPQSKKRK
190 200 210 220 230 240
ISDNLLKKNM VPLNPNRIIP DETSLFLESI LLHQIIGADL STIEILNRLK LDYITEFKFK
250 260 270 280 290 300
NFVIAKGAPI GKSIVSLLLR CKKTLTLDRF IDTLLEDIAV LIKEISVHPN ESKLAVPFLV
310 320 330 340 350 360
ALMYQIVQFR PSATHNLALK DCFLFICDLI RIYHHVLKVP IHESNMNLHV EPQIFQYELI
370 380 390 400 410 420
DYLIISYSFD LLEGILRVLQ SHPKQTYMEF FDENILKSFE FVYKLALTIS YKPMVNVIFS
430 440 450 460 470 480
AVEVVNIITS IILNMDNSSD LKSLISGSWW RDCITRLYAL LEKEIKSGDV YNENVDTTTL
490 500 510 520 530 540
HMSKYHDFFG LIRNIGDNEL GGLISKLIYT DRLQSVPRVI SKEDIGMDSD KFTAPIIGYK
550 560 570 580 590 600
MEKWLLKLKD EVLNIFENLL MIYGDDATIV NGEMLIHSSK FLSREQALMI ERYVGQDSPN
610 620 630 640 650 660
LDLRCHLIEH TLTIIYRLWK DHFKQLREEQ IKQVESQLIM SLWRFLVCQT ETVTANEREM
670 680 690 700 710 720
RDHRHLVDSL HDLTIKDQAS YYEDAFEDLP EYIEEELKMQ LNKRTGRIMQ VKYDEKFQEM
730 740
ARTILESKSF DLTTLEEADS LYISMGL