Q04183
PR
Gene name |
TRS120 (YDR407C, D9509.25, ESBP10) |
Protein name |
Trafficking protein particle complex II-specific subunit 120 |
Names |
TRAPP II-specific subunit 120, Transport protein particle 120 kDa subunit |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR407C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for Q04183
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7E2C | EM | 418 A | J | 1-1289 | PDB |
| 7E2D | EM | 371 A | J | 1-1289 | PDB |
| 7E8S | EM | 436 A | J/U | 1-1289 | PDB |
| 7E8T | EM | 380 A | J | 1-1289 | PDB |
| 7E93 | EM | 654 A | J/U | 1-1289 | PDB |
| 7E94 | EM | 467 A | J/U | 1-1289 | PDB |
| 7EA3 | EM | 431 A | J/W | 1-1289 | PDB |
| 7U05 | EM | 370 A | A/a | 1-1289 | PDB |
| 7U06 | EM | 420 A | A/a | 1-1289 | PDB |
| AF-Q04183-F1 | Predicted | AlphaFoldDB |
18 variants for Q04183
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1287834 | 33 | N>D | No | SGRP | |
| s04-1287540 | 131 | T>A | No | SGRP | |
| s04-1286554 | 459 | E>D | No | SGRP | |
| s04-1286221 | 570 | S>R | No | SGRP | |
| s04-1286207 | 575 | N>S | No | SGRP | |
| s04-1286063 | 623 | L>S | No | SGRP | |
| s04-1285817 | 705 | V>A | No | SGRP | |
| s04-1285422 | 837 | G>R | No | SGRP | |
| s04-1285232 | 900 | M>T | No | SGRP | |
| s04-1285220 | 904 | D>G | No | SGRP | |
| s04-1285131 | 934 | L>V | No | SGRP | |
| s04-1284975 | 986 | P>S | No | SGRP | |
| s04-1284867 | 1022 | V>L | No | SGRP | |
| s04-1284765 | 1056 | V>L | No | SGRP | |
| s04-1284710 | 1074 | S>L | No | SGRP | |
| s04-1284288 | 1215 | I>V | No | SGRP | |
| s04-1284107 | 1275 | G>E | No | SGRP | |
| s04-1284102 | 1277 | I>F | No | SGRP |
No associated diseases with Q04183
No regional properties for Q04183
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q04183 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| TRAPPII protein complex | A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| early endosome to Golgi transport | The directed movement of substances from early endosomes to the Golgi. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNILKHFPSY | VGPSKIRTLV | IPIGHWTRKE | FNNAVQKLSE | FNEIHLSDVT | PIDSPIFTPQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFPHGKLFFD | FLTIDHDDAL | ELFLYDFEPF | RKTFVIIGLV | NDYSDPLTNL | NFMKEKYPTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISPNLVYASS | TPTKELEQTI | DTMENVFASS | PDMQKNIETI | MCDIARNFLT | ALNSYYSSYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVTLRSPGAI | GGNAVLKTTL | IRQNSYTSSS | SSTPMSAVQS | SVSSSSKAGS | VTTASKRLSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FEMTTNSLKR | SASLKLATTL | STSENRSQQK | SLGRQMKILG | NFQLLAGRYV | DALNSFVDAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTLYKVRDYL | WLGSALDGIS | ICFLLLSYLG | LSYQIPQIVS | LICPVEKLNF | ESSSTGISPV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DSNSKATAST | TASSTPRNSI | SIAAMQSPRN | SIMSLSAPAL | NIDVENINLP | LLIKCISDKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LYYYDLSLMH | NSEYAPQVVY | CEFLLKTLTF | MTSCYKSSEF | SKDVLDNIVK | NQHRALSDIP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NSPMFPRFEV | YFYSNKLFEL | QLKEMQVEAQ | IKIYSTMAEV | YRLLGYKRKQ | LFVLRLLMVA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLATPNKIAW | HPDYRTLIDT | IIELLNINES | EAKINVDDPS | QSTWLILQKK | ILQLCIKVSR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KINDFEYVAK | FSSILITKYT | HLLNQSEQDA | LFKEYIQPSI | TNESITSYWD | PFILREVVIN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RILDSDPTSN | EIPLESDVSS | LESLENRQKT | QDINPQEVFN | PFKRVQPTSF | VSNNSTKVPI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LVFLVGDKAE | FTCRVQNPFK | FDFTINDIQL | DEEISEFCEI | DRKAVSYSGP | YNVKAESIRS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ITLPLIIKKP | TYKKIYEISC | LKISILKLPL | QKFDIINDSR | RSNPVEEEAE | YSKCIYGKLK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKILPEQPQL | ELLSTSKMTR | NSWMMLDGTK | TDFHITVRNK | SLSCAINHIK | IIPMNNIEQM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LKPDYWKKMP | PDDLYIMEKQ | LDWLSKSCVR | IIKLPTVIKP | NETITFDLEL | DNTAVPFNFT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GFDLLIEYGM | SATDESCIYL | KKLSIPYEVT | LRRTIEVPSM | DIIPLNELFS | SQVENVDWIE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YVMSKIRAES | NLHSRDFILL | LLDFRNSWID | GIKLNVQFED | FTSNEYHVEA | SHTSRIIVPI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KKIDYKKYNF | ENTPIPRIYP | GRQFIQSGLN | EEQTIEMRQK | FWCREHIISK | LKCNWKLTTD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| QSVTGSVDFN | KFIEKFDHKM | VYTIYPGRLF | YGVQLLLDEP | KVKVGEIINL | KIITEPTSTC |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| RRKQNSTVNF | LDIVIFDSKT | SKILPRSNRR | ILYNGSLTKP | ISTTKVSEIN | LEIIPIEKGR |
| 1270 | 1280 | ||||
| YEFSVCISKS | NNQDGIIQFD | SENVILSVI |