AiPD: Autoinhibited Protein Database

Gene name	UTP5 (YDR398W, D9509.17)
Protein name	U3 small nucleolar RNA-associated protein 5
Names	U3 snoRNA-associated protein 5, U three protein 5, U3 protein 5 required for transcription, t-UTP5
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YDR398W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

234-310 (Predicted disordered autoinhibitory region) PR

234-310 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5WLC	EM	380 A	LL	1-643	PDB
6KE6	EM	340 A	A5	1-643	PDB
6LQP	EM	320 A	A5	1-643	PDB
6LQQ	EM	410 A	A5	1-643	PDB
6LQR	EM	860 A	A5	1-643	PDB
6LQS	EM	380 A	A5	1-643	PDB
6LQT	EM	490 A	A5	1-643	PDB
6LQU	EM	370 A	A5	1-643	PDB
6LQV	EM	480 A	A5	1-643	PDB
6ND4	EM	430 A	L	1-643	PDB
6ZQA	EM	440 A	UE	1-643	PDB
6ZQB	EM	390 A	UE	1-643	PDB
6ZQC	EM	380 A	UE	1-643	PDB
6ZQD	EM	380 A	UE	1-643	PDB
6ZQE	EM	710 A	UI	1-643	PDB
7AJT	EM	460 A	UE	1-643	PDB
7AJU	EM	380 A	UE	1-643	PDB
7D4I	EM	400 A	A5	1-643	PDB
7D5S	EM	460 A	A5	1-643	PDB
7D5T	EM	600 A	A5	1-643	PDB
7D63	EM	1230 A	A5	1-643	PDB
7SUK	EM	399 A	LL	3-557	PDB
AF-Q04177-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s04-1267481	7	Q>E	No	SGRP
s04-1267562	34	T>P	No	SGRP
s04-1267644	61	T>M	No	SGRP
s04-1267835	125	A>T	No	SGRP
s04-1267908	149	N>S	No	SGRP
s04-1268265	268	R>K	No	SGRP
s04-1268307	282	V>A	No	SGRP
s04-1268480	340	S>P	No	SGRP
s04-1268639	393	P>T	No	SGRP
s04-1269366	635	A>V	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q04177

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus	Associated with ribosomal chromatin, even in the absence of transcription
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
rDNA heterochromatin	A region of heterochromatin located at the rDNA repeats in a chromosome.
small-subunit processome	A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
t-UTP complex	A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

Name	Definition
No GO annotations for molecular function

Name	Definition
maturation of SSU-rRNA	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
positive regulation of transcription by RNA polymerase I	Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins