Q04081

PR
Gene name
PPM1 (YDR435C)
Protein name
Leucine carboxyl methyltransferase 1
Names
Protein phosphatase methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR435C
EC number
2.1.1.233: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-298 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q04081

Entry ID Method Resolution Chain Position Source
1RJD X-ray 180 A A/B/C 1-328 PDB
1RJE X-ray 200 A A/B/C 1-328 PDB
1RJF X-ray 225 A A/B/C 1-328 PDB
1RJG X-ray 261 A A 1-328 PDB
2OB1 X-ray 190 A A/B/C 10-328 PDB
2OB2 X-ray 192 A A/B/C 2-328 PDB
AF-Q04081-F1 Predicted AlphaFoldDB

16 variants for Q04081

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1333931 11 D>N No SGRP
s04-1333700 88 A>T No SGRP
s04-1333691 91 E>K No SGRP
s04-1333670 98 K>E No SGRP
s04-1333608 118 M>I No SGRP
s04-1333599 121 H>Q No SGRP
s04-1333549 138 S>N No SGRP
s04-1333519 148 I>T No SGRP
s04-1333516 149 S>F No SGRP
s04-1333489 158 A>V No SGRP
s04-1333462 167 G>E No SGRP
s04-1333400 188 V>I No SGRP
s04-1333255 236 G>D No SGRP
s04-1333118 282 I>V No SGRP
s04-1333111 284 N>S No SGRP
s04-1333091 291 N>Y No SGRP

No associated diseases with Q04081

No regional properties for Q04081

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q04081

Functions

Description
EC Number 2.1.1.233 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
protein C-terminal leucine carboxyl O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein.

3 GO annotations of biological process

Name Definition
C-terminal protein methylation The methylation of the C-terminal amino acid of a protein.
protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of autophagy Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERIIQQTDY DALSCKLAAI SVGYLPSSGL QRLSVDLSKK YTEWHRSYLI TLKKFSRRAF
70 80 90 100 110 120
GKVDKAMRSS FPVMNYGTYL RTVGIDAAIL EFLVANEKVQ VVNLGCGSDL RMLPLLQMFP
130 140 150 160 170 180
HLAYVDIDYN ESVELKNSIL RESEILRISL GLSKEDTAKS PFLIDQGRYK LAACDLNDIT
190 200 210 220 230 240
ETTRLLDVCT KREIPTIVIS ECLLCYMHNN ESQLLINTIM SKFSHGLWIS YDPIGGSQPN
250 260 270 280 290 300
DRFGAIMQSN LKESRNLEMP TLMTYNSKEK YASRWSAAPN VIVNDMWEIF NAQIPESERK
310 320
RLRSLQFLDE LEELKVMQTH YILMKAQW