Q04080
Gene name |
GPI17 (YDR434W, D9461.20) |
Protein name |
GPI transamidase component GPI17 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR434W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q04080
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04080-F1 | Predicted | AlphaFoldDB |
5 variants for Q04080
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1331291 | 21 | L>F | No | SGRP | |
| s04-1331494 | 89 | R>Q | No | SGRP | |
| s04-1331830 | 201 | G>V | No | SGRP | |
| s04-1332039 | 271 | A>T | No | SGRP | |
| s04-1332556 | 443 | L>Q | No | SGRP |
No associated diseases with Q04080
No regional properties for Q04080
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q04080 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| GPI-anchor transamidase complex | An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of GPI anchor to protein | A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. |
| fungal-type cell wall organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNANLRKWV | GFCFVAIYLF | LGVPLWYKLT | TVYRASLPIN | YIESLQNNKF | QDIHLVIPVY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VKSDTYRFPD | VHDAIQVQVN | HLLNSQEQRV | PWSLQVLPYN | ETIEQMESEG | NQFHVVTLKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DEFIGYSSAY | DTKETLVYYD | DAAVLSNDLP | FFVAQTLVEH | TFQLEWTHLN | KTCEGVSTNN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVAISYDPNI | HLSVTLLSGD | GNPVAWEIEP | TLTDYFSPFR | KFLSPLVNFT | VDSSIVYHND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNLHSLNGSC | TSVTWFDLSH | TIDLSELSSM | AYYPEDSALN | LAIVFPSASS | SPDGLAFING |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TRISDEITTL | DWNSYLVPQW | GVIIINKMPL | KPNSVISEDY | LEPMMYRFAT | DIFQLLGLTE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSQDLLSPYI | TIDSFKRLTI | LQNLDKATET | LWSLVKLTQQ | FQGMSIPREV | SDNVIEALDL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RLQIIDLLND | PGKGGDIVWN | NALHLSNELV | KLCEKAFFNG | EMVQQNFFPQ | EHMIAVYLPL |
| 490 | 500 | 510 | 520 | 530 | |
| LGPISAVMFF | GFYNVMKEKN | QKSKKNGTER | EVAKEKLELK | EAQKLHAIDG | EDEL |