Q03YQ2

PR
Gene name
alaS (LEUM_0556)
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)
KEGG Pathway
lme:LEUM_0556
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03YQ2

Entry ID Method Resolution Chain Position Source
AF-Q03YQ2-F1 Predicted AlphaFoldDB

No variants for Q03YQ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03YQ2

No associated diseases with Q03YQ2

4 regional properties for Q03YQ2

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 868 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKDLSSAEIR QMFLDFFASK GHEVVPSKNL IPQDDPTLLW INSGVATLKK YFDGTVVPNN
70 80 90 100 110 120
PRITNSQKAI RTNDIENVGK TARHHTLFEM MGNFSIGDYF KEQAIPWAWE LLTSPEWYGL
130 140 150 160 170 180
DAEKLYVTVY PKDQEARKIW EEKTSLPDGH IYEVEDNFWD IGEGPSGPDS EIFFDRGSSF
190 200 210 220 230 240
QDLPDDDPEM YPGGENERYL EIWNLVFSQF NHLPGLTDNS QYPELPHKNI DTGMGLERVV
250 260 270 280 290 300
SVFQNGRTNF DTDLFLPIIR ATEKLSNQFT YDDSQDSEVN TSFKVIADHI RAITFAIGDG
310 320 330 340 350 360
ALPSNEGRGY VIRRLLRRAV LHGQKLGIKG QFLTNLVPIV GDIMESYYPE VKANTAKIQK
370 380 390 400 410 420
TVAAEEKRFN ATLTGGLSLL NDVIKEAKKT GQTQISGADA FKLSDTYGFP LELTQEQAED
430 440 450 460 470 480
AGLTVDVDRY NDELQAQRVR ARAARSNTKS MGVQNAVLTD LRVDSKYVGW SQTEVNHAEI
490 500 510 520 530 540
VAIIGEDEQG VDALLDNADV DATVQVAFDV TPFYAEMGGQ VPDFGDVLNT NGDVIAHVTD
550 560 570 580 590 600
VQTAPNGQHI HTVDVISSFT LGDKVDLKVD MARHIAVSKN HTATHMLDQS LRNVLGGDVH
610 620 630 640 650 660
QAGSLVEPEY LRFDFNNEGP VSSEDLDKIE SMMNQEIAKN LPVTWLETDI ESAKKLGAVA
670 680 690 700 710 720
VFGEKYGDQV RVVSIGDFNK EFDGGTHANS TAELGLFKIV SESGIGAGVR RIEAVTGLQA
730 740 750 760 770 780
LSQYKAQEKA LKEIATALKA QKLTDAPEKV YDLQADLRTV QRHAESLEAK LANATAGEIF
790 800 810 820 830 840
NDVKTVNGHT YITAQLQVSG MDGLRQVADN WKENYPSDVL VLATVADEKV SLIVAAAPDA
850 860 870 880 890
NQSGIKAGEL IKSIAPHIGG GGGGRPDMAQ AGGKKPAGIP DAFAAVSAFL ADK