Q03B02

PR
Gene name
alaS (LSEI_0784)
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei)
KEGG Pathway
lca:LSEI_0784
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03B02

Entry ID Method Resolution Chain Position Source
AF-Q03B02-F1 Predicted AlphaFoldDB

No variants for Q03B02

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03B02

No associated diseases with Q03B02

5 regional properties for Q03B02

Type Name Position InterPro Accession
domain DHHA1 domain 738 - 877 IPR003156
domain Aminoacyl-tRNA synthetase, class II 62 - 252 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKMSSGEIR QMFLDFFKSK GHAVEPSASL IPVDDPTLLW INSGVATLKK YFDGSVVPDN
70 80 90 100 110 120
PRITNAQKSI RTNDIENVGK TARHLTFFEM LGNFSVGDYF KKEVIPWAWE LLTSPKWFGF
130 140 150 160 170 180
DPKRLYVTVY PKDKVTKELW QKTGVPDDHI VEAEDNFWDI GEGPSGPDSE IFYDRGQQFN
190 200 210 220 230 240
NVAEDDPENY PGGENSRYVE IWNIVFSELN HLPDGRFVEQ PHKNIDTGMG LERLVAVIQG
250 260 270 280 290 300
TPTIFETDLF MPIIKATEKM SAGKRYGVSA QDDVSFKIIA DHARTVTFAI GDGALPSNEG
310 320 330 340 350 360
RGYVLRRLIR RAVLNGKKLG IDHDFLYQLV PVVGEIMKSY YPQILANQQF IQKVIESEEA
370 380 390 400 410 420
RFRQTLDAGV TLLNQIIADL KQDGKKEIPG ADAFKLFDTY GFPVEMTNEY AQDEGLQVDM
430 440 450 460 470 480
AGFKKNMAAQ RDRARKARGD RQSMGSQDKV LMSITTPSKF TGWTELDHKH ASLQTIVVND
490 500 510 520 530 540
QLQDSVSEGT AQLIFDETPF YAEMGGQVAD HGEIKAQDGT VLADVSDVQH APNGQNLHTV
550 560 570 580 590 600
TVKGKLETGQ QYWLSVDPLR RKKVSLNHTA THLLDQALRD VLGEHTHQAG SLVEPDYLRF
610 620 630 640 650 660
DFTNFGQVTP KQLRQVETIV NQKIWDALPI TWKEMPIEEA KKLGAIAMFG DKYGSVVRIV
670 680 690 700 710 720
KIGDYNTEFD GGTHPTNSNA LGLFKITSES GIGAGIRRVE AVTSKEAYEY LTQQQDWLSE
730 740 750 760 770 780
TAENLKIDQV KNVPSKVTQL QADLKAEQKT VAGLQAKLAA QAAAGIFDHP EEVGGLKLIA
790 800 810 820 830 840
KQVQVAGMNE LRQLADKWKA KQASDILVLG TEVSGKANLL VAVNDTANQA GFKAGDLIKA
850 860 870 880
IAPKVGGGGG GRPDMAQAGG KNPAGIPAAL SEAKTVISQK A