Q03956

PR
Gene name
RAV2 (YDR202C, YD9346.12C)
Protein name
Regulator of V-ATPase in vacuolar membrane protein 2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR202C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

216-295 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03956

Entry ID Method Resolution Chain Position Source
AF-Q03956-F1 Predicted AlphaFoldDB

2 variants for Q03956

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-857416 179 E>K No SGRP
s04-857296 219 R>* No SGRP

No associated diseases with Q03956

No regional properties for Q03956

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q03956

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • May be membrane-associated and localize to early endosomes via its interaction with RAV1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
early endosome membrane The lipid bilayer surrounding an early endosome.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
RAVE complex A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly.
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.
vacuolar proton-transporting V-type ATPase complex assembly The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O17213 H14A12.3 Protein rogdi homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MSVDLFPNDR FGAEDKYDNF KDAVKECSWL IEEIVKPQLP NIIDNFSKCL EMLESDQIFK
70 80 90 100 110 120
MPVSNGIPNE SNKQNDSPTV KGVITRQGQY IVDFHIVVRF PQFQRGKQVM FRMNTGLNFL
130 140 150 160 170 180
LIQFSKIMTH LKNILEILNQ LQVATDVSEF VSKFGVAMEL LNHSLILLQN PPRDLVFPED
190 200 210 220 230 240
NNFAMKEMFQ DCYSVCESTA HILGLELTLC RNELCIELRN LIKVTKKPWC EIDSKTGRSF
250 260 270 280 290 300
CDQIRNQVTN ERNKTLSKIL SENGVQVQDS TLLNHIISSF QSEAITLPEA QELLRRGVTF
310 320 330 340 350
DNRVVMECEK LIVSTSDPTL ISISAKLNSL KASMANHQAN LVASKQLSTY K