AiPD: Autoinhibited Protein Database

Gene name	MTC5 (SEA3, YDR128W)
Protein name	Maintenance of telomere capping protein 5
Names	SEH-associated protein 3
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YDR128W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

465-800 (Predicted disordered autoinhibitory region) PR

465-800 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8ADL	EM	295 A	C/Q	1-1148	PDB
8AE6	EM	270 A	Q	1-1148	PDB
AF-Q03897-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s04-709550	2	C>F	No	SGRP
s04-710368	275	I>V	No	SGRP
s04-710374	277	L>I	No	SGRP
s04-710488	315	C>R	No	SGRP
s04-710489	315	C>Y	No	SGRP
s04-710620	359	K>Q	No	SGRP
s04-710670	375	R>S	No	SGRP
s04-710993	483	L>P	No	SGRP
s04-711311	589	I>T	No	SGRP
s04-711349	602	S>T	No	SGRP
s04-711607	688	L>V	No	SGRP
s04-711608	688	L>W	No	SGRP
s04-711706	721	D>N	No	SGRP
s04-711712	723	F>L	No	SGRP
s04-711757	738	I>V	No	SGRP
s04-711781	746	I>L	No	SGRP
s04-711928	795	L>I	No	SGRP
s04-711953	803	G>E	No	SGRP
s04-712304	920	A>V	No	SGRP
s04-712420	959	A>T	No	SGRP
s04-712424	960	R>K	No	SGRP
s04-712471	976	P>T	No	SGRP
s04-712856	1104	R>K	No	SGRP
s04-712921	1126	I>L	No	SGRP

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	14 - 51	IPR001680-1
repeat	WD40 repeat	55 - 97	IPR001680-2
repeat	WD40 repeat	103 - 146	IPR001680-3
repeat	WD40 repeat	147 - 186	IPR001680-4
repeat	WD40 repeat	190 - 239	IPR001680-5
repeat	WD40 repeat	290 - 339	IPR001680-6
domain	RWD domain	432 - 543	IPR006575
conserved_site	WD40 repeat, conserved site	130 - 144	IPR019775

		Description
EC Number
Subcellular Localization	Vacuole membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extrinsic component of fungal-type vacuolar membrane	The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
fungal-type vacuole membrane	The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
Seh1-associated complex	A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.
vacuolar membrane	The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

Name	Definition
signaling adaptor activity	The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

Name	Definition
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
positive regulation of TORC1 signaling	Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of TORC1 signaling	Any process that modulates the frequency, rate or extent of TORC1 signaling.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins