Q03771

PR
Gene name
ACL4
Protein name
Assembly chaperone of RPL4
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR161W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03771

Entry ID Method Resolution Chain Position Source
AF-Q03771-F1 Predicted AlphaFoldDB

6 variants for Q03771

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-779158 40 N>S No SGRP
s04-779178 47 V>M No SGRP
s04-779217 60 K>E No SGRP
s04-779424 129 V>M No SGRP
s04-779867 276 I>M No SGRP
s04-780024 329 V>I No SGRP

No associated diseases with Q03771

No regional properties for Q03771

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q03771

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Distributed throughout the cell but is enriched in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
protein transporter activity Directly binding to a specific protein and delivering it to a specific cellular location.
unfolded protein binding Binding to an unfolded protein.

7 GO annotations of biological process

Name Definition
'de novo' cotranslational protein folding The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
metaphase/anaphase transition of mitotic cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSELEATIRQ AKEALAENNA KKALKILKPF KSSLKKENAN NVILNEVFAD AYLDNGQVEK
70 80 90 100 110 120
AYPILARACE LDPEGQVGGP DKFFTMGQIM GGQDGVSIIT RGIMNISNTG GEMLTNVQVE
130 140 150 160 170 180
KIVGGLLSVI EIWMTDLCME PNAEEQCEEL IQKAMELTEG KSPETWSTLG SIKISQQKFG
190 200 210 220 230 240
EAYEAFSQAW NFFELKKQEI GSGINENGDT TQKAGLQSEY VDLLQPLLSL TKMCLEVGAY
250 260 270 280 290 300
EVALKVIAAV RDIDEDNIEG YYLEGFTYYL MSKLEIFKLN NPEVSLRPEN IYEFNQLIQE
310 320 330 340 350 360
VPLDLSHEPI SQLIYDSRLA LSFALQAGVN ADSKDEIVQE LLGGANALLQ EIGGPLDPSE
370 380
LTQIKKGDLV NENEDLEELD IEEEYSD