Q03768

PR
Gene name
GIR2 (DFRP2, YDR152W, YD8358.08)
Protein name
Protein GIR2
Names
DRG family-regulatory protein 2, Genetically interacts with ribosomal genes protein 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR152W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03768

Entry ID Method Resolution Chain Position Source
AF-Q03768-F1 Predicted AlphaFoldDB

2 variants for Q03768

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-766029 109 K>N No SGRP
s04-766077 125 E>D No SGRP

No associated diseases with Q03768

1 regional properties for Q03768

Type Name Position InterPro Accession
domain RWD domain 5 - 159 IPR006575

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
polysome A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

1 GO annotations of molecular function

Name Definition
protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

5 GO annotations of biological process

Name Definition
cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
negative regulation of protein-containing complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
positive regulation of cellular response to amino acid starvation Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYKEEQKQE LEVLESIYPD ELRIINDEYP KIKFEVAIKL ELDTGDSTSV LTKEHTIIAE
70 80 90 100 110 120
FKLPENYPDE PCLISLEAQE VALNDNEEDN EEDEDEVEYD DHGNKVLKKF ENLPDLISFK
130 140 150 160 170 180
GYLPELTVQL ESQIETDMLL GMQMCFALIS SIKERCEQWY SEQLNKLEKQ YELEAQEREK
190 200 210 220 230 240
KEQAKFHGTK VTRESYLEWR SKFRQELKLD ERDQVRRMKA HHGKLTGKQM FEQGVVGTGD
250 260
EYMEEDDASV DDVAKGLAKT EIANQ