AiPD: Autoinhibited Protein Database

Gene name	SRC1 (HEH1, YML034W, YML033W)
Protein name	Inner nuclear membrane protein SRC1
Names	Helix-extension-helix domain-containing protein 1
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YML034W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

4-473 (Predicted disordered autoinhibitory region) PR

4-473 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
4XZR	X-ray	225 A	A	170-223	PDB
AF-Q03707-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s13-209646	41	A>V	No	SGRP
s13-209723	67	S>G	No	SGRP
s13-209750	76	R>S	No	SGRP
s13-209924	134	P>S	No	SGRP
s13-209940	139	S>N	No	SGRP
s13-210029	169	N>Y	No	SGRP
s13-210117	198	H>L	No	SGRP
s13-210116	198	H>N	No	SGRP
s13-210162	213	Q>R	No	SGRP
s13-210212	230	G>R	No	SGRP
s13-210384	287	T>I	No	SGRP
s13-210513	330	R>K	No	SGRP
s13-210518	332	P>T	No	SGRP
s13-210558	345	E>G	No	SGRP
s13-210609	362	G>A	No	SGRP
s13-210609	362	G>D	No	SGRP
s13-210620	366	N>H	No	SGRP
s13-210839	439	G>R	No	SGRP
s13-210877	451	L>F	No	SGRP
s13-210915	464	F>S	No	SGRP
s13-211211	563	Q>K	No	SGRP
s13-211631	661	V>L	No	SGRP
s13-211916	756	D>N	No	SGRP
s13-211950	767	Q>R	No	SGRP
s13-212132	828	D>N	No	SGRP

Type	Name	Position	InterPro Accession
domain	Man1/Src1, C-terminal	464 - 820	IPR018996
domain	HeH/LEM domain	14 - 48	IPR025856

		Description
EC Number
Subcellular Localization	Nucleus inner membrane ; Multi-pass membrane protein	Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
nuclear periphery	The portion of the nuclear lumen proximal to the inner nuclear membrane.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

Name	Definition
establishment of mitotic sister chromatid cohesion	The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle.
maintenance of rDNA	Any process involved in sustaining the fidelity and copy number of rDNA repeats.
mitotic sister chromatid segregation	The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins