Q03585

PR
Gene name
rpo1N
Protein name
DNA-directed RNA polymerase subunit Rpo1N
Names
DNA-directed RNA polymerase subunit A'
Species
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
KEGG Pathway
tac:Ta0391
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-362 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03585

Entry ID Method Resolution Chain Position Source
AF-Q03585-F1 Predicted AlphaFoldDB

No variants for Q03585

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03585

No associated diseases with Q03585

6 regional properties for Q03585

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 317 - 490 IPR000722
domain RNA polymerase, N-terminal 207 - 518 IPR006592
domain RNA polymerase Rpb1, domain 3 493 - 657 IPR007066
domain RNA polymerase Rpb1, domain 1 6 - 315 IPR007080
domain RNA polymerase Rpb1, domain 5 796 - 861 IPR007081
domain RNA polymerase Rpb1, domain 4 684 - 789 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMGISKRISS IKFALLSPDE IRKLSQVKVI TADTYDDDGY PIEHGLMDLH MGVIEPGLRC
70 80 90 100 110 120
ATCGGKVDEC PGHFGHIELA MPVVHVGFVK EIKMFLDATC RSCGRIKLTD DEIRTYLPEI
130 140 150 160 170 180
QKMDFETGDP EDIEILTKKY VDLASQRMVC PHCGAQQSKI ILDKPTTFRE EGTNVKITPK
190 200 210 220 230 240
EIRERLERIP DDDLIFFGFN PKTARPEWMV LTVLPVPPIN VRPSITLETG ERSEDDLTHK
250 260 270 280 290 300
LVDIIRISQR LRESRDNGSP QLIIEDLWDL LQFHVTTYFD NQTPGIPPAR HRSGRALKTL
310 320 330 340 350 360
VQRLKGKEGR FRSNLSGKRV SFSSRTVISP EPYLSVNEVG VPERAARELT VPVIVNQFNI
370 380 390 400 410 420
DEMRELIKRG RNPRDQFGRY VTGVNYVIRP DGRRIKITDQ NAAENADRID IGWTVERQLM
430 440 450 460 470 480
EGDIVLFNRQ PSLHRMSMMG HTVRILPGQT FRFNLAVCTP YNADFDGDEM NLHVIQKEEA
490 500 510 520 530 540
RAEARIIMKV QEQIMSPRFG GPIIGGIHDH VTALFLLTHN NPRYTHEEMV HIMAYLEPDL
550 560 570 580 590 600
LPEARIENGE KYYYGRDIFS TILPKGLNVR FRSKLCSGSS ERCEFEDDPS DTYVEIVDGK
610 620 630 640 650 660
MIHGTIDEAA VSPFSGAIID KIFRKFGSQE AARFIDRMTR LAVGFITYRG FSTGISDYDI
670 680 690 700 710 720
PESAVARIEE LVAQAEDRIN KLIETFRRGE LQPAPGRSVE DTLEMEILSE AGVVRDESGK
730 740 750 760 770 780
IASSYLGLKV PSVIMARSGA RATMLNISEV AGIVGQQSVR GGRLNRGYYN RTLPHFKRGD
790 800 810 820 830 840
IGADARGFVR SSYMTGLSPT EYFFHSIGGR EGLVDTAVRT SRSGYMQRRL INAFEDLKVD
850 860 870 880
DSREVKDTVG SLIQIRYGED GIDPTRSARG KAVDMNYILF DEERR