Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q03378
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q03378-F1 | Predicted | AlphaFoldDB |
No variants for Q03378
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q03378 | |||||
No associated diseases with Q03378
4 regional properties for Q03378
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 222 - 399 | IPR002314 |
| domain | Aminoacyl-tRNA synthetase, class II | 139 - 409 | IPR006195 |
| domain | Serine-tRNA synthetase, type1, N-terminal | 1 - 109 | IPR015866 |
| domain | Serine-tRNA ligase catalytic core domain | 121 - 415 | IPR033729 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRGKIEIKR | IENSSNRQVT | YSKRRNGIMK | KAKEISVLCD | AHVSVIIFAS | SGKMHEFCSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STTLVDMLDH | YHKLSGKRLW | DPKHEHLDNE | INRVKKENDS | MQIELRHLKG | EDITTLNYKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMVLEDALEN | GTSALKNKQM | EFVRMMRKHN | EMVEEENQSL | QFKLRQMHLD | PMNDNVMESQ |
| 190 | 200 | 210 | |||
| AVYDHHHHQN | IADYEAQMPF | AFRVQPMQPN | LQERF |