Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q03378

Entry ID Method Resolution Chain Position Source
AF-Q03378-F1 Predicted AlphaFoldDB

No variants for Q03378

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03378

No associated diseases with Q03378

4 regional properties for Q03378

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 222 - 399 IPR002314
domain Aminoacyl-tRNA synthetase, class II 139 - 409 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 109 IPR015866
domain Serine-tRNA ligase catalytic core domain 121 - 415 IPR033729

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

1 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGRGKIEIKR IENSSNRQVT YSKRRNGIMK KAKEISVLCD AHVSVIIFAS SGKMHEFCSP
70 80 90 100 110 120
STTLVDMLDH YHKLSGKRLW DPKHEHLDNE INRVKKENDS MQIELRHLKG EDITTLNYKE
130 140 150 160 170 180
LMVLEDALEN GTSALKNKQM EFVRMMRKHN EMVEEENQSL QFKLRQMHLD PMNDNVMESQ
190 200 210
AVYDHHHHQN IADYEAQMPF AFRVQPMQPN LQERF