Q03364

PR
Gene name
fgfr2
Protein name
Fibroblast growth factor receptor 2
Names
FGFR-2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

372-479 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

633-658 (Activation loop from InterPro)

Target domain

471-760 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q03364

Entry ID Method Resolution Chain Position Source
AF-Q03364-F1 Predicted AlphaFoldDB

No variants for Q03364

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03364

No associated diseases with Q03364

16 regional properties for Q03364

Type Name Position InterPro Accession
domain Protein kinase domain 471 - 760 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 471 - 747 IPR001245
domain Immunoglobulin subtype 2 49 - 110 IPR003598-1
domain Immunoglobulin subtype 2 161 - 228 IPR003598-2
domain Immunoglobulin subtype 2 259 - 339 IPR003598-3
domain Immunoglobulin subtype 43 - 117 IPR003599-1
domain Immunoglobulin subtype 155 - 239 IPR003599-2
domain Immunoglobulin subtype 253 - 350 IPR003599-3
domain Immunoglobulin-like domain 35 - 105 IPR007110-1
domain Immunoglobulin-like domain 145 - 237 IPR007110-2
domain Immunoglobulin-like domain 246 - 348 IPR007110-3
active_site Tyrosine-protein kinase, active site 612 - 624 IPR008266
domain Immunoglobulin I-set 159 - 238 IPR013098-1
domain Immunoglobulin I-set 253 - 349 IPR013098-2
binding_site Protein kinase, ATP binding site 477 - 507 IPR017441
domain Tyrosine-protein kinase, catalytic domain 471 - 747 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
  • Golgi apparatus
  • Cytoplasmic vesicle
  • Detected on osteoblast plasma membrane lipid rafts
  • After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

2 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLLALLAFL LVSRTIARPS YSMVDDTTPE PEEPPAKYQI SKADVFPVLP GEPLDLRCPL
70 80 90 100 110 120
ADGPLVTWTK DGAKLEVNNR TLIVRTYLQI KESTTRDSGL YACSVLKNSH FFHVNVTEAS
130 140 150 160 170 180
SSGDDEDDND GSEDFTNDNN NIRAPYWTNT EKMEKKLHAV SAANTVKLRC PAREPHPSNE
190 200 210 220 230 240
WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGIYT CIVENEHGSI NHTYHLDVIE
250 260 270 280 290 300
RSSHRPILQA GLPANTTAVV GGDAEFVCKV YSDAQPHIRW VRYIEKNGSR FGVDGLPYFK
310 320 330 340 350 360
VLKAAGVNVT DEEIEVLYVR NVSFEDAGEY TCIAGNSIGI SQHSAWLTVH PAPVNPLEDN
370 380 390 400 410 420
PVPYYMEIGI YSTGIFIIFC MVVVCVVCRM RQGAKKKKNF TGPPVHKLTK RIPLHRQVTV
430 440 450 460 470 480
SADSSSSMNS TTPLVRITTR LLNSTDAMPL ANVSEYELPH DPMWEFSRDK LTLGKPLGEG
490 500 510 520 530 540
CFGQVVMAEA LGIDKERPKE SVTVAVKMLK DNATEKDLAD LVSEMEMMKM IGKHKNIINL
550 560 570 580 590 600
LGACTQGGTL YVIVEYAAKG NLRQYLRARR PLEMEYSFDV TRVPDEQMTF KDLVSCTYQI
610 620 630 640 650 660
ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD VNNIDYYKKT SNGRLPVKWM
670 680 690 700 710 720
APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTN
730 740 750 760 770 780
ELYMMMRDCW HAIPSHRPTF KQLVEDLDRI LTLTTNEEYL DLSAPLEQYS PSFPDSSCSA
790 800 810
SSSSGDDSVF SPDPMPHDPC LPKFQHVNGV VKT