Q03319

PR
Gene name
prh1 (SPAC2G11.11c)
Protein name
Probable ATP-dependent RNA helicase prh1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC2G11.11c
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03319

Entry ID Method Resolution Chain Position Source
AF-Q03319-F1 Predicted AlphaFoldDB

10 variants for Q03319

Variant ID(s) Position Change Description Diseaes Association Provenance
I_831385_T_C 39 K>E No Jeffares_SNPs
I_831309_G_A 64 A>V No Jeffares_SNPs
I_831273_T_A 76 E>V No Jeffares_SNPs
I_831252_G_A 83 P>L No Jeffares_SNPs
I_831198_G_A 101 A>V No Jeffares_SNPs
I_830429_C_A 357 L>F No Jeffares_SNPs
I_830221_C_T 427 A>T No Jeffares_SNPs
I_829707_A_T 598 F>Y No Jeffares_SNPs
I_829638_T_G 621 D>A No Jeffares_SNPs
I_829296_G_T 693 S>Y No Jeffares_SNPs

No associated diseases with Q03319

6 regional properties for Q03319

Type Name Position InterPro Accession
domain Helicase, C-terminal 294 - 466 IPR001650
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 211 - 220 IPR002464
domain Helicase-associated domain 486 - 576 IPR007502
domain DEAD/DEAH box helicase domain 106 - 254 IPR011545
domain DEAD-box helicase, OB fold 639 - 713 IPR011709
domain Helicase superfamily 1/2, ATP-binding domain 94 - 278 IPR014001

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKVSGKLRN GGSITKQNLT DGLVGGQRIK APNKKKNRKA SKNTTKKSTV SVVNFLEQDT
70 80 90 100 110 120
DFGANEVVGS DNSSPEKRSE NSPSKRKDIL EQRKNLPIWE AHDTLCQQIQ DNRVIVVVGE
130 140 150 160 170 180
TGSGKSTQIP QFLNECPYAQ EGCVAITQPR RVAAVNLAKR VAAEQGCRLG EQVGYSIRFD
190 200 210 220 230 240
DTTSKKTRIK YLTDGMLLRE LINDPILSQY HTLILDEAHE RTLMTDMLLG FVKKIIKKRP
250 260 270 280 290 300
ALRVIIMSAT LNAERFSEFF DGAEICYISG RQYPVQIHYT YTPEPDYLDA CLRTIFQLHT
310 320 330 340 350 360
KLPPGDILVF LTGQDEIEAL EALIKSYSKQ LPSNLPQIQA CPLFASLPQE QQLQVFLPAL
370 380 390 400 410 420
ANHRKVVLST NIAETSVTIS GIRYVIDTGL AKIKQFNSKL GLESLTVQPI SQSAAMQRSG
430 440 450 460 470 480
RAGREAAGQC YRIYTEADFD KLPKETIPEI KRIDLSQAVL TLKARGQNDV INFHYMDPPS
490 500 510 520 530 540
KEGLLRALEH LYSIGALDDN GHINDLGYQM SLIPLLPSLA RAVLAAREHN CLSEVIDVVS
550 560 570 580 590 600
CLSTDSMFLF PQEKRDEAIE ARLKFLHSEG DLLTCLNALR QYLESSHDSR KQWCSQNFIN
610 620 630 640 650 660
RRALKTILDI RKQLREHCLK DGWELNSSPE VNSENLLLSF LSGYITNTAL LHPDGSYRTI
670 680 690 700 710
IGNQTISIHP SSSLFGKKVE AIMYHELVFT TKSYVRGVSS IRSNWLNAVA PHYLARRST