Q03290

PR
Gene name
TFB3 (RIG2, YDR460W)
Protein name
RNA polymerase II transcription factor B subunit 3
Names
RNA polymerase II transcription factor B 38 kDa subunit, RNA polymerase II transcription factor B p38 subunit
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR460W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

110-280 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

21 structures for Q03290

Entry ID Method Resolution Chain Position Source
5OQJ EM 470 A 3 1-321 PDB
5OQM EM 580 A 3 1-321 PDB
6GYM EM 670 A 3 1-321 PDB
6XI8 EM 364 A C 259-321 PDB
7KUE EM 350 A C 1-321 PDB
7ML0 EM 300 A 3 1-321 PDB
7ML1 EM 400 A 3 1-321 PDB
7ML2 EM 340 A 3 1-321 PDB
7ML3 EM 760 A 3 1-321 PDB
7ML4 EM 310 A 3 1-321 PDB
7O4I EM 320 A 3 1-321 PDB
7O4J EM 290 A 3 1-321 PDB
7O4K EM 360 A 3 1-321 PDB
7O4L EM 340 A 3 1-321 PDB
7O72 EM 340 A 3 1-321 PDB
7O73 EM 340 A 3 1-321 PDB
7O75 EM 320 A 3 1-321 PDB
7ZS9 EM 310 A 3 1-321 PDB
7ZSA EM 400 A 3 1-321 PDB
7ZSB EM 660 A 3 1-321 PDB
AF-Q03290-F1 Predicted AlphaFoldDB

2 variants for Q03290

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1383981 60 D>G No SGRP
s04-1384505 235 K>Q No SGRP

No associated diseases with Q03290

3 regional properties for Q03290

Type Name Position InterPro Accession
domain Zinc finger, RING-type 11 - 60 IPR001841
domain Cdk-activating kinase assembly factor MAT1, centre 63 - 248 IPR015877
conserved_site Zinc finger, RING-type, conserved site 34 - 43 IPR017907

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
transcription factor TFIIH holo complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

2 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
metal ion binding Binding to a metal ion.

7 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLMDEYEENK DMCPICKTDR YLSPDVKFLV NPECYHRICE SCVDRIFSLG PAQCPYKGCD
70 80 90 100 110 120
KILRKNKFKT QIFDDVEVEK EVDIRKRVFN VFNKTIDDFN GDLVEYNKYL EEVEDIIYKL
130 140 150 160 170 180
DHGIDVAKTE EKLRTYEELN KQLIMNNLER SRTEIESFEQ RQKFEKEMKL KKRLLERQIE
190 200 210 220 230 240
EEERMNKEWT KKEIVNRLST TTQDINETIE GVKNTVKLKK SSARRKLEEL NRVLKNNPYF
250 260 270 280 290 300
NSNVNVQNSR LKDAVPFTPF NGDREAHPRF TLKGSVYNDP FIKDLEHRKE FIASGFNTNY
310 320
AYERVLTEAF MGLGCVISEE L