Q03212
Gene name |
EAR1 (YMR171C, YM8010.01C, YM8520.20C) |
Protein name |
Protein EAR1 |
Names |
Endosomal adapter of RSP5 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR171C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q03212
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q03212-F1 | Predicted | AlphaFoldDB |
7 variants for Q03212
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-605170 | 117 | N>S | No | SGRP | |
| s13-605161 | 120 | D>V | No | SGRP | |
| s13-605047 | 158 | G>E | No | SGRP | |
| s13-605017 | 168 | P>R | No | SGRP | |
| s13-605012 | 170 | T>A | No | SGRP | |
| s13-603986 | 512 | T>A | No | SGRP | |
| s13-603894 | 542 | D>E | No | SGRP |
No associated diseases with Q03212
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFKFLIESL | LLGSISGQIR | CGRSSVIPRG | DVSYGGDDTD | ELNMDIMLFA | FGTLIVVYIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ICIVYFFTKQ | IATRLITAYY | NEHGPGQRIS | LFSDYDENNA | HVHSRRLMEN | MSLRWPNNLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DADEVRDKLA | QLSPEEQFYY | KQGEEYIKQN | PPFLLNQGLL | QQSEDSNPDT | TREDPIMNEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRQYIQEEGA | YAWEFSPNPD | MPNHTVIVEN | KTEVSFLNYN | YDASISTNLP | IPCINKVYYC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EFKIFETDGP | LNSDENVSKG | VISFGLSTQP | YPYFRLPGRH | HHSIAYDSNG | ARRFNDSFKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEQLRTLFPQ | CEKGDIVGIG | YRSRSGTVFF | TRNGKKLNEK | SVGGHIRGWK | FQYLYPIIGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVPCQIHVNF | GTYGFVYIEA | NVKKWGYAKS | NGIKLPPPSY | EDYGKDTLLE | SGGEDNDFDE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DFSDGDSDNI | AAGSTTNLND | DIIIRNGEIL | PPPPGFEFTM | SPPTGKKIIN | EEINLDSLPM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LPPSYSDDEH | HSKNDKSAIS | GRIIGTSRNL | ITDEASFDSV | DNDNEDENDH | ERDPEQFSEF |
| DDYESRMHGI |