Q03012
Gene name |
SPP1 (CPS40, SAF41, YPL138C) |
Protein name |
COMPASS component SPP1 |
Names |
Complex proteins associated with SET1 protein SPP1, Set1C component SPP1, Suppressor of PRP protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL138C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q03012
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6BX3 | EM | 430 A | F | 117-353 | PDB |
| 6J2P | X-ray | 285 A | A/B/C/D | 1-124 | PDB |
| 6VEN | EM | 337 A | R | 2-353 | PDB |
| AF-Q03012-F1 | Predicted | AlphaFoldDB |
7 variants for Q03012
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-292392 | 12 | T>S | No | SGRP | |
| s16-292176 | 84 | G>V | No | SGRP | |
| s16-292163 | 88 | L>F | No | SGRP | |
| s16-291934 | 165 | V>I | No | SGRP | |
| s16-291896 | 177 | Q>H | No | SGRP | |
| s16-291820 | 203 | F>V | No | SGRP | |
| s16-291409 | 340 | L>V | No | SGRP |
No associated diseases with Q03012
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| metal ion binding | Binding to a metal ion. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H3-K4 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of meiotic DNA double-strand break formation | Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation. |
| subtelomeric heterochromatin assembly | The compaction of chromatin into heterochromatin at the subtelomeric region. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLPQWCPPH | STLKRNPTTG | EDVYCICKRP | DYGELMVGCD | GCDDWFHFTC | LHIPEQFKDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VFSFYCPYCQ | AGITGKNKDA | IINGEGSLPK | TLWKRKCRIS | DCYKPCLQDS | KYCSEEHGRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FVNDIWSRLK | TDEDRAVVKK | MVEQTGHIDK | FKKFGQLDFI | DNNIVVKTDD | EKEIFDQIVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDMTLKTLED | DLQEVQEISL | PLFKKKLELL | EVYLGWLDNV | YTEMRKLDDD | AASHVECGKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSKGTKRKKK | KNSSRSRARK | NICGYCSTYE | RIPCSVEEFV | RDFGSNEEAT | KIHEVCTKWK |
| 310 | 320 | 330 | 340 | 350 | |
| CNRHLDWVST | NQEQYLQQID | SLESMQERLQ | HLIQARKKQL | NIQYYEEILR | RGL |