Q02965

PR
Gene name
thrb (nr1a2)
Protein name
Thyroid hormone receptor beta
Names
Nuclear receptor subfamily 1 group A member 2
Species
Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q02965

Entry ID Method Resolution Chain Position Source
AF-Q02965-F1 Predicted AlphaFoldDB

No variants for Q02965

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q02965

No associated diseases with Q02965

2 regional properties for Q02965

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 129 - 373 IPR000536
domain Zinc finger, nuclear hormone receptor-type 16 - 93 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
thyroid hormone binding Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSSMSGYIP SYLDKDELCV VCGDKATGYH YRCITCEGCK GFFRRTIQKN LHPSYSCKYE
70 80 90 100 110 120
GKCVIDKVTR NQCQECRFKK CIAVGMATDL VLDDSKRLAK RKLIEENREK RRKDELQKTL
130 140 150 160 170 180
VQKPEPTPEE WELIQVVTEA HVATNAQGSH WKQKRKFLPE DIGQAPIVNA PEGGKVDLEA
190 200 210 220 230 240
FSQFTKIITP AITRVVDFAK KLPMFCELPC EDQIILLKGC CMEIMSLRAA VRYDPESETL
250 260 270 280 290 300
TLNGEMAVTR GQLKNGGLGV VSDAIFDLGV SLSSFNLDDT EVALLQAVLL MSSDRPGLSS
310 320 330 340 350 360
VERIEKCQEG FLLAFEHYIN YRKHNVAHFW PKLLMKVTDL RMIGACHASR FLHMKVECPT
370
ELFPPLFLEV FED