Q02955

PR
Gene name
Il1r1 (Il1ra)
Protein name
Interleukin-1 receptor type 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q02955

Entry ID Method Resolution Chain Position Source
AF-Q02955-F1 Predicted AlphaFoldDB

No variants for Q02955

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q02955

No associated diseases with Q02955

8 regional properties for Q02955

Type Name Position InterPro Accession
domain Toll/interleukin-1 receptor homology (TIR) domain 386 - 548 IPR000157
domain Immunoglobulin subtype 38 - 117 IPR003599-1
domain Immunoglobulin subtype 130 - 215 IPR003599-2
domain Immunoglobulin subtype 236 - 333 IPR003599-3
domain Immunoglobulin-like domain 16 - 115 IPR007110-1
domain Immunoglobulin-like domain 121 - 217 IPR007110-2
domain Immunoglobulin-like domain 229 - 331 IPR007110-3
domain IL-1Ra-like, immunoglobulin domain 57 - 111 IPR041416

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
  • Cell membrane
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell surface The external part of the cell wall and/or plasma membrane.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

8 GO annotations of molecular function

Name Definition
interleukin-1 binding Binding to interleukin-1.
interleukin-1 receptor activity Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
interleukin-1, type I, activating receptor activity Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.
ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide.
NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity.
platelet-derived growth factor receptor binding Binding to a platelet-derived growth factor receptor.
protease binding Binding to a protease or a peptidase.

18 GO annotations of biological process

Name Definition
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
heat acclimation Any process that increases heat tolerance of an organism in response to high temperatures.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
interleukin-1-mediated signaling pathway The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
ovulation The release of a mature ovum/oocyte from an ovary.
positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-1-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway.
positive regulation of neuron migration Any process that activates or increases the frequency, rate or extent of neuron migration.
positive regulation of neutrophil extravasation Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.
positive regulation of T-helper 1 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production.
regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
response to epidermal growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
response to nitric oxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.
response to radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
response to transforming growth factor beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14778 IL1R1 Interleukin-1 receptor type 1 Homo sapiens (Human) PR
P13504 Il1r1 Interleukin-1 receptor type 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MENMKVLLGF ICLIVPLLSL ETDKCTEYPN EVISFSSVNE IDIRSCPLTP NEMHGGTIIW
70 80 90 100 110 120
YKNDSKTPIS ADKDSRIHQQ NEHLWFVPAK MEDSGYYYCI MRNSTYCLKT KITMSVLEND
130 140 150 160 170 180
PGLCYNTQAS FIQRLHVAGD GSLVCPYLDF FKDENNELPK VQWYKNCKPL PLDDGNFFGF
190 200 210 220 230 240
KNKLMVMNVA EEHRGNYTCR TSYTYQGKQY PVTRVITFIT IDDSKRDRPV IMSPRNETME
250 260 270 280 290 300
ADPGSTIQLI CNVTGQFTDL VYWKWNGSEI EWDDPILAED YQFLEHPSAK RKYTLITTLN
310 320 330 340 350 360
VSEVKSQFYR YPFICFVKNT HILETAHVRL VYPVPDFKNY LIGGFAIFTA TAVFCACIYK
370 380 390 400 410 420
VFKVDIVLWY RDSCSDFLPR KASDGRTYDA YVLYPKTYGE GSFAYLDTFV FKLLPEVLEG
430 440 450 460 470 480
QFGYKLFICG RDDYVGEDTI EVTNENVKRS RRLIIILVRD MGSFSCLGQS SEEQIAIYDA
490 500 510 520 530 540
LIREGIKIIL LELEKIQDYE KMPESIQFIK QKHGAICWSG DFKERPQSAK TRFWKNLRYQ
550 560 570
MPAQRRSPLS KHHLLTLDPV LDTKEKLQAE THLPLG