Q02940
Gene name |
penA |
Protein name |
Beta-lactamase |
Names |
Penicillinase |
Species |
Burkholderia multivorans (strain ATCC 17616 / 249) |
KEGG Pathway |
|
EC number |
3.5.2.6: In cyclic amides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q02940
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q02940-F1 | Predicted | AlphaFoldDB |
No variants for Q02940
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q02940 | |||||
No associated diseases with Q02940
1 regional properties for Q02940
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Beta-lactamase, class-C active site | 186 - 193 | IPR001586 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.2.6 | In cyclic amides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| outer membrane-bounded periplasmic space | The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-lactamase activity | Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| antibiotic catabolic process | The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. |
| response to antibiotic | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRIGVTDYT | ILGTVKGAEL | ELVRFTHPFM | GFDVPAILGD | HVTRMPVPVP | FTPRLPRPGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCDRSEIRPG | KPLTRLARTA | LICRALIRRW | MARTSYSDSV | NCHTQPISAI | FDYKDLRFEP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSNRISPAGQ | TSVDRLLQLS | QGQAVEGQSA | VARLTGEKKN | HPGAQYANRL | SPRIANNHPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQQTLFELGS | GAKERNAINV | SYLTALGTPG | FTLMLPARML | CGIVSDNNFT | QKQLCPSPAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTRGPAEPAK | RGPWLEPGLV | IRKDGLRTGK | LLSSLRGLCL | TVLRFQPTVP | CFCRLALSSS |
| 310 | |||||
| VAISSTGLVN | FSR |