Q02939

PR
Gene name
TFB2 (YPL122C)
Protein name
General transcription and DNA repair factor IIH subunit TFB2
Names
TFIIH subunit TFB2, RNA polymerase II transcription factor B 52 kDa subunit, RNA polymerase II transcription factor B p52 subunit, RNA polymerase II transcription factor B subunit 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL122C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

26 structures for Q02939

Entry ID Method Resolution Chain Position Source
3DGP X-ray 180 A A 435-513 PDB
3DOM X-ray 260 A A/C 412-513 PDB
5FMF EM 600 A W 447-508 PDB
5OQJ EM 470 A 2 1-513 PDB
5OQM EM 580 A 2 1-513 PDB
5SVA EM 1530 A a 1-513 PDB
6GYM EM 670 A 2 1-513 PDB
7K01 EM 390 A 2 1-513 PDB
7K04 EM 925 A 2 1-513 PDB
7M2U EM 820 A 2 1-513 PDB
7ML0 EM 300 A 2 1-513 PDB
7ML1 EM 400 A 2 1-513 PDB
7ML2 EM 340 A 2 1-513 PDB
7ML3 EM 760 A 2 1-513 PDB
7ML4 EM 310 A 2 1-513 PDB
7O4I EM 320 A 2 1-513 PDB
7O4J EM 290 A 2 1-513 PDB
7O4K EM 360 A 2 1-513 PDB
7O4L EM 340 A 2 1-513 PDB
7O72 EM 340 A 2 1-513 PDB
7O73 EM 340 A 2 1-513 PDB
7O75 EM 320 A 2 1-513 PDB
7ZS9 EM 310 A 2 1-513 PDB
7ZSA EM 400 A 2 1-513 PDB
7ZSB EM 660 A 2 1-513 PDB
AF-Q02939-F1 Predicted AlphaFoldDB

3 variants for Q02939

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-320551 72 L>F No SGRP
s16-320553 72 L>V No SGRP
s16-320354 138 Y>F No SGRP

No associated diseases with Q02939

1 regional properties for Q02939

Type Name Position InterPro Accession
domain Transcription factor Tfb2, C-terminal domain 439 - 506 IPR040662

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleotide-excision repair factor 3 complex One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).
transcription factor TFIIH core complex The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.
transcription factor TFIIH holo complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.

2 GO annotations of molecular function

Name Definition
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
double-stranded DNA binding Binding to double-stranded DNA.

4 GO annotations of biological process

Name Definition
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYSLKHSV TQYLEEIPQQ VQNRLYTSPA TCLAIYRILP PLAKFFIMAM VFNENEVPLL
70 80 90 100 110 120
DLDKWVNSNG KLQFQNAIKS MKSLHLLIPN KSSGTLMINL NPTFKISLRN ALTGGEVQNS
130 140 150 160 170 180
FGVVVEENVV SLDLLDEYSA NKWETILHFM VGTPLAKIPS EKVLNLLKHS KLMEEVNSTG
190 200 210 220 230 240
EFKITNEGFQ FLLQEINSQL WTLLLQYLKM IETSKMDLVD VLHFIFMLGA LEVGKAYKID
250 260 270 280 290 300
ALSETQRIML QDMRDYGLVF QKHSNDSIFY PTKLALMLTS DTKTIRSASN AMDSVLRQNR
310 320 330 340 350 360
EEPSVNEDGA NGKSTTDITT SDDLNKAGLK NQDIPDGSLI VETNFKIYSY SNSPLQIAVL
370 380 390 400 410 420
SLFVHLKARF VNMVLGQITR ESIRRALTNG ITADQIIAYL ETHAHPQMRR LAEEKLEKKL
430 440 450 460 470 480
ELDPNCKEPL QVLPPTVVDQ IRLWQLELDR VITYEGSLYS DFETSQEYNL LSKYAQDIGV
490 500 510
LLWKDDKKKK FFISKEGNSQ VLDFAKRKLK KKQ