Q02732
Gene name |
CTF19 (MCM18, YPL018W, LPB13W) |
Protein name |
Inner kinetochore subunit CTF19 |
Names |
CENP-P homolog, Chromosome transmission fidelity protein 19, Constitutive centromere-associated network protein CTF19, Minichromosome maintenance protein 18 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL018W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for Q02732
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5W94 | X-ray | 319 A | E/H | 1-6 | PDB |
| 6NUW | EM | 425 A | D | 1-369 | PDB |
| 6QLD | EM | 415 A | P | 97-366 | PDB |
| 6QLE | EM | 355 A | P | 1-369 | PDB |
| 6QLF | EM | 345 A | P | 1-369 | PDB |
| 8OVW | EM | 340 A | P | 1-369 | PDB |
| 8OVX | EM | 340 A | P | 1-369 | PDB |
| 8OW0 | EM | 340 A | P | 1-369 | PDB |
| 8OW1 | EM | 370 A | P/PP | 1-369 | PDB |
| AF-Q02732-F1 | Predicted | AlphaFoldDB |
7 variants for Q02732
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-517686 | 13 | T>I | No | SGRP | |
| s16-517815 | 56 | K>R | No | SGRP | |
| s16-518012 | 122 | R>G | No | SGRP | |
| s16-518055 | 136 | K>M | No | SGRP | |
| s16-518477 | 277 | S>G | No | SGRP | |
| s16-518516 | 290 | R>G | No | SGRP | |
| s16-518588 | 314 | C>R | No | SGRP |
No associated diseases with Q02732
No regional properties for Q02732
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q02732 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| COMA complex | A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of spindle microtubules to kinetochore | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| establishment of mitotic sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| mitotic spindle assembly checkpoint signaling | A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| protein localization to chromosome, centromeric region | Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFTSDTTNS | HDTSNSHLSL | EDAVGTHHAG | EADVNIDGDE | KQQLSLLDDD | QVRALKLQEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDALLTRRNT | LLQEIQTYQN | ILMKENNSKT | KNGDILQNDI | TQDFLNLISI | SSSNPNSAIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DRKRVERING | LTNLQKELVT | KYDTLPLLNM | NLRLSYLRDH | TYPHLQVSVQ | SRDRVHNDGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVLVVNYKFC | RNTMNPFEIQ | FKMFYKFEDS | TLLKWEILRI | STNVRLKAKQ | LLATRNFQKC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLSLYEFDKI | KSKKTGIFQN | LINLLKRKTR | CYLMNNSDSL | IVERVIREGR | LTTIKLQINF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IITMPGERGK | PRNCFLPMSK | ISIALWKGGE | RFNQIDLDEI | CYGLIKEYGV | KTGLKEICNV |
| CLFPDMYAR |