Q02720

PR
Gene name
casK (DDB_G0276885)
Protein name
Casein kinase II subunit alpha
Names
CK II subunit alpha
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0276885
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

182-204 (Activation loop from InterPro)

Target domain

47-332 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q02720

Entry ID Method Resolution Chain Position Source
AF-Q02720-F1 Predicted AlphaFoldDB

No variants for Q02720

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q02720

No associated diseases with Q02720

3 regional properties for Q02720

Type Name Position InterPro Accession
domain Carbamoyl-phosphate synthase small subunit, N-terminal domain 9 - 146 IPR002474
domain Glutamine amidotransferase 188 - 366 IPR017926
domain Carbamoyl-phosphate synthase small subunit, GATase1 domain 187 - 364 IPR035686

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
asexual reproduction A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNHSSKKNKN RILRNKARIY CDVNLHKPKE YWNYEALNVK WETQDDYEII RKIGRGKYSE
70 80 90 100 110 120
VFEGANIKNN EKCVIKVLKP VKKKKIKREI KILQNLCGGP NIITLYDVVR DPQSKTPSLI
130 140 150 160 170 180
FEYINNTDFK HLSPTLTDFD VRYYIRELLH ALDFCHSNGI MHRDVKPSNV MIDHQKRKLY
190 200 210 220 230 240
LIDWGLAEFY HPNQDYNVRV ASRPYKGPEL LVDMEDYDYS LDMWSLGCMF AGMLFQKDPF
250 260 270 280 290 300
FHGHDNIDQL VKIVKILGTE EFYAYLDKYG IVVDHTILSI IGKHPKKPWS RFITKENQHL
310 320 330
AVPEAIDFLE KLLRYDPAER LTTREAMEHP YFKPLSH