Q02595

PR
Gene name
PK2
Protein name
Probable serine/threonine-protein kinase 2
Names
Species
Plasmodium falciparum (isolate K1 / Thailand)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

250-271 (Activation loop from InterPro)

Target domain

111-364 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q02595

Entry ID Method Resolution Chain Position Source
AF-Q02595-F1 Predicted AlphaFoldDB

No variants for Q02595

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q02595

No associated diseases with Q02595

3 regional properties for Q02595

Type Name Position InterPro Accession
domain Protein kinase domain 111 - 364 IPR000719
active_site Serine/threonine-protein kinase, active site 226 - 238 IPR008271
binding_site Protein kinase, ATP binding site 117 - 140 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKRYQQLFK GKRIDFPLAT GAASHVSLTY DEKKNPYLLC WTYIYQEKPE FTVPLKGCRI
70 80 90 100 110 120
INNITEIGPC IHIITSNEEY QFQCRSKEEF DEMSQFFNML GYPILGFKNV YVLNKKIGKG
130 140 150 160 170 180
SFSTAYIGTN ILYGNRVVVK EVDKSKVKES NVYTEIEVLR KVMHKYIIKL ISAYEQEGFV
190 200 210 220 230 240
YLVLEYLKGG ELFEYLNNNG PYTEQVAKKA MKRVLIALEA LHSNGVVHRD LKMENLMLEN
250 260 270 280 290 300
PNDPSSLKII DFGLASFLNS PSMNMRCGSP GYVAPEILKC ASYGTKVDIF SLGVILFNIL
310 320 330 340 350 360
CGYPPFRGNN VKEIFKKNMR CHISFNTKHW INKSESVKEI ILWMCCKNPD DRCTALQALG
370 380 390 400 410 420
HQWFLPKLTD MHMTANINEL KRNEAIVHKS NDQQDMCKKC KHFNNTQNDD IYNNNNNNNQ
430 440 450 460 470 480
LDPNKNHKNN YNDYKNYFDT MLKIDDKYSE NLIKDKTSMD SISLNKKDYD AYLVHSNEHD
490 500
TVVLHGKCQT TKNSSSLLSY KCSRRSPPQN