Q02374
Gene name |
NDUFB2 |
Protein name |
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial |
Names |
Complex I-AGGG, CI-AGGG, NADH-ubiquinone oxidoreductase AGGG subunit |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:327713 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
25 structures for Q02374
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7DGQ | EM | 500 A | Y | 37-108 | PDB |
| 7DGR | EM | 460 A | Y | 37-108 | PDB |
| 7DGS | EM | 780 A | Y | 37-108 | PDB |
| 7DGZ | EM | 380 A | Y | 37-108 | PDB |
| 7DH0 | EM | 420 A | Y | 37-108 | PDB |
| 7DKF | EM | 830 A | Y2 | 37-108 | PDB |
| 7QSD | EM | 310 A | j | 1-108 | PDB |
| 7QSK | EM | 284 A | j | 1-108 | PDB |
| 7QSL | EM | 276 A | j | 1-108 | PDB |
| 7QSM | EM | 230 A | j | 1-108 | PDB |
| 7QSN | EM | 281 A | j | 1-108 | PDB |
| 7QSO | EM | 302 A | j | 1-108 | PDB |
| 7R41 | EM | 230 A | j | 1-108 | PDB |
| 7R42 | EM | 230 A | j | 1-108 | PDB |
| 7R43 | EM | 240 A | j | 1-108 | PDB |
| 7R44 | EM | 240 A | j | 1-108 | PDB |
| 7R45 | EM | 240 A | j | 1-108 | PDB |
| 7R46 | EM | 240 A | j | 1-108 | PDB |
| 7R47 | EM | 230 A | j | 1-108 | PDB |
| 7R48 | EM | 230 A | j | 1-108 | PDB |
| 7R4C | EM | 230 A | j | 1-108 | PDB |
| 7R4D | EM | 230 A | j | 1-108 | PDB |
| 7R4F | EM | 240 A | j | 1-108 | PDB |
| 7R4G | EM | 250 A | j | 1-108 | PDB |
| AF-Q02374-F1 | Predicted | AlphaFoldDB |
57 variants for Q02374
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs472583409 | 2 | A>G | No | EVA | |
| rs471586572 | 4 | M>V | No | EVA | |
| rs463476321 | 5 | S>L | No | EVA | |
| rs443414374 | 5 | S>T | No | EVA | |
| rs463476321 | 5 | S>W | No | EVA | |
| rs480295222 | 6 | A>G | No | EVA | |
| rs442483974 | 7 | L>M | No | EVA | |
| rs445498829 | 8 | K>N | No | EVA | |
| rs479412868 | 8 | K>T | No | EVA | |
| rs465649551 | 9 | R>G | No | EVA | |
| rs482253039 | 9 | R>P | No | EVA | |
| rs467746528 | 10 | L>V | No | EVA | |
| rs436451877 | 11 | A>E | No | EVA | |
| rs436451877 | 11 | A>G | No | EVA | |
| rs436451877 | 11 | A>V | No | EVA | |
| rs466943282 | 12 | P>L | No | EVA | |
| rs451519358 | 13 | F>L | No | EVA | |
| rs432324518 | 13 | F>V | No | EVA | |
| rs471668618 | 14 | A>S | No | EVA | |
| rs457118822 | 15 | H>P | No | EVA | |
| rs473937466 | 15 | H>Q | No | EVA | |
| rs443477222 | 15 | H>Y | No | EVA | |
| rs442545671 | 16 | V>A | No | EVA | |
| rs442545671 | 16 | V>G | No | EVA | |
| rs459407217 | 17 | G>R | No | EVA | |
| rs459215548 | 19 | H>N | No | EVA | |
| rs451047605 | 19 | H>Q | No | EVA | |
| rs482316439 | 19 | H>R | No | EVA | |
| rs481382957 | 20 | L>P | No | EVA | |
| rs461385191 | 20 | L>V | No | EVA | |
| rs446921964 | 21 | F>L | No | EVA | |
| rs432399528 | 22 | R>S | No | EVA | |
| rs446008807 | 23 | G>S | No | EVA | |
| rs437089970 | 24 | R>G | No | EVA | |
| rs457180111 | 24 | R>L | No | EVA | |
| rs474000976 | 25 | C>G | No | EVA | |
| rs474000976 | 25 | C>S | No | EVA | |
| rs436156388 | 25 | C>W | No | EVA | |
| rs452957096 | 26 | A>E | No | EVA | |
| rs473118612 | 27 | R>S | No | EVA | |
| rs438425174 | 28 | A>G | No | EVA | |
| rs458374066 | 29 | A>P | No | EVA | |
| rs458374066 | 29 | A>S | No | EVA | |
| rs461446805 | 33 | G>C | No | EVA | |
| rs447014257 | 34 | V>G | No | EVA | |
| rs481446335 | 34 | V>L | No | EVA | |
| rs460631957 | 36 | R>G | No | EVA | |
| rs454432306 | 45 | P>L | No | EVA | |
| rs471250591 | 55 | R>I | No | EVA | |
| rs433399241 | 58 | V>E | No | EVA | |
| rs433399241 | 58 | V>G | No | EVA | |
| rs476754660 | 60 | Q>L | No | EVA | |
| rs442151090 | 63 | F>V | No | EVA | |
| rs462183724 | 65 | S>I | No | EVA | |
| rs472653119 | 75 | R>P | No | EVA | |
| rs441166569 | 79 | D>A | No | EVA | |
| rs460486446 | 83 | V>G | No | EVA |
No associated diseases with Q02374
No regional properties for Q02374
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q02374 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial respiratory chain complex I | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial respiratory chain complex I assembly | The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGMSALKRL | APFAHVGGHL | FRGRCARAAG | ARGVRRAGGG | AHIEPRYRQF | PQLTRSQVIQ |
| 70 | 80 | 90 | 100 | ||
| AEFFSATMWF | WILWRFWHDS | DAVLGHFPYP | DPSQWTDEEL | GIPPDDED |