Q02369

PR
Gene name
NDUFB9 (UQOR22)
Protein name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Names
Complex I-B22, CI-B22, NADH-ubiquinone oxidoreductase B22 subunit
Species
Bos taurus (Bovine)
KEGG Pathway
bta:327660
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

29 structures for Q02369

Entry ID Method Resolution Chain Position Source
5LC5 EM 435 A n 11-137 PDB
5LDW EM 427 A n 11-137 PDB
5LDX EM 560 A n 11-137 PDB
5O31 EM 413 A n 2-179 PDB
7DGQ EM 500 A f 2-179 PDB
7DGR EM 460 A f 2-179 PDB
7DGS EM 780 A f 2-179 PDB
7DGZ EM 380 A f 2-179 PDB
7DH0 EM 420 A f 2-179 PDB
7DKF EM 830 A f2 2-179 PDB
7QSD EM 310 A n 1-179 PDB
7QSK EM 284 A n 1-179 PDB
7QSL EM 276 A n 1-179 PDB
7QSM EM 230 A n 1-179 PDB
7QSN EM 281 A n 1-179 PDB
7QSO EM 302 A n 1-179 PDB
7R41 EM 230 A n 1-179 PDB
7R42 EM 230 A n 1-179 PDB
7R43 EM 240 A n 1-179 PDB
7R44 EM 240 A n 1-179 PDB
7R45 EM 240 A n 1-179 PDB
7R46 EM 240 A n 1-179 PDB
7R47 EM 230 A n 1-179 PDB
7R48 EM 230 A n 1-179 PDB
7R4C EM 230 A n 1-179 PDB
7R4D EM 230 A n 1-179 PDB
7R4F EM 240 A n 1-179 PDB
7R4G EM 250 A n 1-179 PDB
AF-Q02369-F1 Predicted AlphaFoldDB

38 variants for Q02369

Variant ID(s) Position Change Description Diseaes Association Provenance
rs465530529 6 S>A No EVA
rs445481653 8 A>D No EVA
rs449742100 23 A>E No EVA
rs449742100 23 A>V No EVA
rs481048561 25 R>* No EVA
rs467342779 26 H>L No EVA
rs467342779 26 H>P No EVA
rs447506928 28 E>A No EVA
rs478725811 32 I>V No EVA
rs458545181 33 H>P No EVA
rs441373220 50 E>* No EVA
rs481705281 52 K>M No EVA
rs461847610 58 V>G No EVA
rs459349489 66 E>* No EVA
rs439501082 76 H>P No EVA
rs470888311 80 Y>H No EVA
rs443405639 84 E>G No EVA
rs463653416 84 E>K No EVA
rs434860493 85 S>F No EVA
rs454832447 85 S>T No EVA
rs452410184 89 T>A No EVA
rs452410184 89 T>P No EVA
rs432401227 93 R>* No EVA
rs470483091 96 C>S No EVA
rs439239570 106 D>V No EVA
rs1114981446 110 S>L No EVA
rs437739995 137 V>E No EVA
rs437739995 137 V>G No EVA
rs445176261 137 V>L No EVA
rs480739244 142 E>G No EVA
rs460668124 146 V>G No EVA
rs446850955 148 G>R No EVA
rs458370449 149 P>T No EVA
rs482437297 157 A>P No EVA
rs482437297 157 A>S No EVA
rs462365570 159 K>E No EVA
rs473680648 172 T>A No EVA
rs453713467 174 P>H No EVA

No associated diseases with Q02369

2 regional properties for Q02369

Type Name Position InterPro Accession
domain Complex 1 LYR protein domain 14 - 71 IPR008011
domain NDUFB9, LYR domain 12 - 88 IPR045292

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0MQF0 NDUFB9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Pan troglodytes (Chimpanzee) PR
Q9Y6M9 NDUFB9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Homo sapiens (Human) PR
10 20 30 40 50 60
MAFLSSGAYL THQQKVLRLY KRALRHLESW CIHRDKYRYF ACLLRARFDE HKNEKDMVKA
70 80 90 100 110 120
TQLLREAEEE FWHGQHPQPY IFPESPGGTS YERYECYKVP EWCLDDWHPS EKAMYPDYFA
130 140 150 160 170
KREQWKKLRR ESWEREVKQL QEETPVGGPR TEALPPARKQ GDLPPLWWHI VTRPRERPM