Q02256

PR
Gene name
YVH1 (YIR026C)
Protein name
Tyrosine-protein phosphatase YVH1
Names
PTPase YVH1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIR026C
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-296 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q02256

Entry ID Method Resolution Chain Position Source
6N8M EM 350 A Y 1-364 PDB
6N8N EM 380 A Y 1-364 PDB
6N8O EM 350 A Y 1-364 PDB
6RZZ EM 320 A s 1-364 PDB
6S05 EM 390 A s 1-364 PDB
AF-Q02256-F1 Predicted AlphaFoldDB

7 variants for Q02256

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-405942 8 V>A No SGRP
s09-405580 129 V>I No SGRP
s09-405531 145 H>P No SGRP
s09-405510 152 P>Q No SGRP
s09-405132 278 A>E No SGRP
s09-405078 296 Q>R No SGRP
s09-405075 297 G>D No SGRP

No associated diseases with Q02256

3 regional properties for Q02256

Type Name Position InterPro Accession
domain Dual specificity phosphatase, catalytic domain 31 - 169 IPR000340
domain Tyrosine-specific protein phosphatases domain 95 - 154 IPR000387
domain Dual specificity protein phosphatase domain 11 - 173 IPR020422

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
preribosome binding Binding to a preribosome.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

6 GO annotations of biological process

Name Definition
ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY
70 80 90 100 110 120
TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG
130 140 150 160 170 180
LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM GGDFVDFDNP
190 200 210 220 230 240
AYKQWKLKQS IKLDPSGSEL VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA
250 260 270 280 290 300
LSTSFIAHDP PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE
310 320 330 340 350 360
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA LPNMVNFESE
KVNR