Q01988

PR
Gene name
USP11
Protein name
Ubiquitin carboxyl-terminal hydrolase 11
Names
Deubiquitinating enzyme 11, Ubiquitin thioesterase 11, Ubiquitin-specific-processing protease 11
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

107-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01988

Entry ID Method Resolution Chain Position Source
AF-Q01988-F1 Predicted AlphaFoldDB

No variants for Q01988

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01988

No associated diseases with Q01988

3 regional properties for Q01988

Type Name Position InterPro Accession
domain Peptidase C19, ubiquitin carboxyl-terminal hydrolase 279 - 409 IPR001394
conserved_site Ubiquitin specific protease, conserved site 354 - 371 IPR018200
domain Ubiquitin specific protease domain 1 - 412 IPR028889

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Chromosome
  • Predominantly nuclear
  • Associates with chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

2 GO annotations of biological process

Name Definition
protein deubiquitination The removal of one or more ubiquitin groups from a protein.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD IFIYEVSGRS
70 80 90 100 110 120
AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL VSVPRDRLSW DALYHILLYR
130 140 150 160 170 180
LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP GHVAGASSQD SGAGSGGAQL WSRRRKPAPV
190 200 210 220 230 240
DNSPGPSHWP QRARRKHLFT LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE
250 260 270 280 290 300
VEAEGYVKHD CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW
310 320 330 340 350 360
MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE LYKYDLIAVS
370 380 390 400 410 420
NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE SKAAYVLFYQ RQDVARRLQP
430 440
QPSSSDPPAS PACGSPPNSE FMDVN