Q01941

PR
Gene name
MIP1
Protein name
DNA polymerase gamma
Names
Allergen Pit o 1, Mitochondrial DNA polymerase catalytic subunit
Species
Komagataella pastoris (Yeast) (Pichia pastoris)
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01941

Entry ID Method Resolution Chain Position Source
AF-Q01941-F1 Predicted AlphaFoldDB

No variants for Q01941

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01941

No associated diseases with Q01941

3 regional properties for Q01941

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family A, palm domain 568 - 906 IPR001098
domain DNA mitochondrial polymerase, exonuclease domain 70 - 355 IPR041336
domain DNA polymerase gamma, palm domain 576 - 929 IPR047580

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
gamma DNA polymerase complex A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIRRFVRHL STSKSSIRIN AVGIQHLAPS LQNQLFGKSS PRLDEDLINM AKRHLKSNNL
70 80 90 100 110 120
IGKKSSLNDP IEIQLPSLQG NTLDEHFYKL GSASLEPYNP LIDELLNLNI IEPQFEFAFQ
130 140 150 160 170 180
SGWTRYAPGE PSEKVPYPLE DSYFFDVETM YKVSQYPVMA VALSDKAWYG WVSPYLTEES
190 200 210 220 230 240
TTNDHLIPLN TFETEKFIVG HNVSYDRARA LEEYNLKQTK AFWMDTMALH VSVSGMCTRQ
250 260 270 280 290 300
RGTWIKHNKK EQENTMSVAS IKSKVQNEEL QELLDSTSIE DPMLEDNPWI NKSSLNSLER
310 320 330 340 350 360
VAEFYCKIKL KKDIRNSFAT EDPDELRGNF DELMQYCAKD VFATGKVFQK VYPKFKKLIP
370 380 390 400 410 420
HPVTLAALKD ISSCILPTTT KWEDYIETSE RLYQESRRMI EKNLHVICEE TVKLKDDPTK
430 440 450 460 470 480
PWENDPWLSQ LDWTIDPIRL TKKGEIHKNQ KLPGYPNWYK QLIVKNELKL TTKTRTSPLL
490 500 510 520 530 540
LKLAWNGNPL YWIQTQGWCF KVPKNKTEEY EKLNFVMVSL KKLSEDPGFE SIRAEDLKNF
550 560 570 580 590 600
TFVKVPHPDG PSARVTNCMT KSCLGFFEKG FLNSQYPLAK DALQMAVASS YWTSSRERIM
610 620 630 640 650 660
NQFVVFEDDM GYILPQIIPM GTITRRAVEN TWLTASNAKK NRLGSELKSL IEAPKGYCFV
670 680 690 700 710 720
GADVDSEELW IASLIGDSVF KIHGGTAIGW MTLEGTKNEG TDLHSKTAKI LGISRNEAKI
730 740 750 760 770 780
FNYGRIYGAG IKFTTTLLKK FNPALSDAEA KATANALYTA TKGISGRYDK KSIWYGGSES
790 800 810 820 830 840
IIFNRLEAIA EMAHPKTPVL GAGITAPLQK ANLSTNNFLT SRINWAIQSS GVDYLHLLII
850 860 870 880 890 900
SMDYLIKLFD IDARLCITVH DEIRYLVKEE DKFRAAYALQ ISNLWTRAMF CQQLGINEVP
910 920 930 940 950 960
QSCAFFSAVD LDFVLRKEVD LDCVTPSNPD PIPCGKSLDI YQLLQQEDIK GADFPRTMHL
970 980 990 1000 1010
NDVHYRKRTP VIEMFDKAVD DKTRKFMVSL QIAQDKTEFT KWKRSRGELI VH