Q01588
Gene name |
rpa1 |
Protein name |
Replication protein A 70 kDa DNA-binding subunit |
Names |
RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:397937 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q01588
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q01588-F1 | Predicted | AlphaFoldDB |
No variants for Q01588
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q01588 | |||||
No associated diseases with Q01588
5 regional properties for Q01588
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 188 - 272 | IPR004365 |
| domain | Replication factor-A protein 1, N-terminal | 6 - 104 | IPR007199 |
| domain | Replication factor A, C-terminal | 452 - 597 | IPR013955 |
| domain | Replication protein A, OB domain | 296 - 393 | IPR031657 |
| domain | Replication factor A, C-terminal, eukaryotes | 436 - 603 | IPR047192 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA replication factor A complex | A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| protein localization to chromosome | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALPQLSEGA | ISAMLGGDSS | CKPTLQVINI | RPINTGNGPP | RYRLLMSDGL | NTLSSFMLAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLNSLVDNNL | LATNCICQVS | RFIVNNLKDG | RRVIIVMELD | VLKSADLVMG | KIGNPQPYND |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GQPQPAAPAP | ASAPAPAPSK | LQNNSAPPPS | MNRGTSKLFG | GGSLLNTPGG | SQSKVVPIAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNPYQSKWTV | RARVTNKGQI | RTWSNSRGEG | KLFSIEMVDE | SGEIRATAFN | EQADKFFSII |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVNKVYYFSK | GTLKIANKQY | TSVKNDYEMT | FNSETSVIPC | DDSADVPMVQ | FEFVSIGELE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SKNKDTVLDI | IGVCKNVEEV | TKVTIKSNNR | EVSKRSIHLM | DSSGKVVSTT | LWGEDADKFD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSRQPVVAIK | GARLSDFGGR | SLSVLSSSTV | MINPDIPEAF | KLRAWFDSEG | QVVEGTSISE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRGGGTGGGN | TNWKSLLEVK | NENLGHGEKA | DYFTSVATIV | YLRKENCLYQ | ACPSQDCNKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VIDQQNGLFR | CEKCNKEFPN | FKYRLILSAN | IADFGENQWI | TCFQESAESI | LGQNATYLGE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKEKNEQAYD | EVFQNANFRS | YTFRARVKLE | TYNDESRIKA | TAVDVKPVDH | KEYSRRLIMN |
| IRKMATQGV |