Q01462

PR
Gene name
ldh1
Protein name
L-lactate dehydrogenase 1
Names
L-LDH 1
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L0017
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01462

Entry ID Method Resolution Chain Position Source
AF-Q01462-F1 Predicted AlphaFoldDB

No variants for Q01462

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01462

No associated diseases with Q01462

3 regional properties for Q01462

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 8 - 145 IPR001236
active_site L-lactate dehydrogenase, active site 175 - 181 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 148 - 316 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADKQRKKVI LVGDGAVGSS YAFALVNQGI AQELGIVDLF KEKTQGDAED LSHALAFTSP
70 80 90 100 110 120
KKIYSADYSD ASDADLVVLT SGAPQKPGET RLDLVEKNLR ITKDVVTKIV ASGFKGIFLV
130 140 150 160 170 180
AANPVDILTY ATWKFSGFPK NRVVGSGTSL DTARFRQALA EKVDVDARSI HAYIMGEHGD
190 200 210 220 230 240
SEFAVWSHAN VAGVKLEQWF QENDYLNEAE IVELFESVRD AAYSIIAKKG ATFYGVAVAL
250 260 270 280 290 300
ARITKAILDD EHAVLPVSVF QDGQYGVSDC YLGQPAVVGA EGVVNPIHIP LNDAEMQKME
310 320
ASGAQLKAII DEAFAKEEFA SAVKN