Q01414

PR
Gene name
ERG
Protein name
Transcriptional regulator ERG homolog
Names
Species
Lytechinus variegatus (Green sea urchin) (Echinus variegatus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

97-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01414

Entry ID Method Resolution Chain Position Source
AF-Q01414-F1 Predicted AlphaFoldDB

No variants for Q01414

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01414

No associated diseases with Q01414

10 regional properties for Q01414

Type Name Position InterPro Accession
domain FERM domain 97 - 378 IPR000299
domain SAB domain 493 - 544 IPR007477
domain Band 4.1, C-terminal 787 - 865 IPR008379
domain FERM adjacent 384 - 430 IPR014847
domain FERM, N-terminal 101 - 163 IPR018979
domain FERM, C-terminal PH-like domain 292 - 382 IPR018980
conserved_site FERM conserved site 151 - 179 IPR019747-1
conserved_site FERM conserved site 258 - 287 IPR019747-2
domain FERM central domain 181 - 288 IPR019748
domain Band 4.1 domain 93 - 288 IPR019749

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
SGQIQLWQFL LELLSDSSNA NCITWEGTNG EFKMTDPDEV ARRWGERKSK PNMNYDKLSR
70 80 90 100 110 120
ALRYYYDKNI MTKVHGKRYA YKFDFAGLAQ AMQPVQADPS MYRYQSDLTY LPGYHPTKLN
130 140 150 160 170
FVGTPINPST NASLFSSHSS YWSSPTGANI YPSGHVTHPH ASHMSSHIGT YYG